Antihypertensive drugs: 5mg amlodipine besylate, 2.5mg L-amlodipine besylate

Amlodipine besylate and L-amlodipine besylate are just two words apart. For most high blood pressure friends, there is no need to struggle. When we take a blood pressure medicine, the most important thing is whether the blood pressure can be reduced to normal, the second is whether there are side effects, and the third is whether it is a long-acting blood pressure medicine. If these 3 basic requirements are met, then we can take it for a long time to lower blood pressure. So what is the difference between these two anti-hypertensive drugs? First, let’s take a look at the history of these two drugs. Amlodipine besylate was released at Pfizer in 1990. Luohuoxi (Norvasc in English, amlodipine besylate tablets) is the world’s prescription One of the largest brand drugs for the treatment of hypertension, it has been used globally for more than 40 billion patient treatment days. This is the earliest amlodipine and the original product. Of course, after the patent protection period, amlodipine besylate also has many domestic medicines, and the domestic amlodipine besylate is a few tenths the price of imported amlodipine besylate, which is one month. Domestic medicine is almost equivalent to buying a piece of imported medicine. L-amlodipine besylate In 1999, Shihuida Company removed the right-hand component of amlodipine, obtained pure L-body for the first time and obtained compound invention patents and intellectual property rights. “L-amlodipine besylate” was born. 2. What does left-handed mean? The earliest amlodipine was a racemate, containing left-handed body and right-handed body, just like human left and right hands, mirror images of each other, but they could not overlap. The study found that the antihypertensive effect of the left-handed body is 1000 times that of the right-handed body, and the right-handed body has almost no antihypertensive effect. And the right-handed body is more likely to cause adverse reactions such as headache, limb edema, and facial flushing. Therefore, after research, to remove the right-handed dextrorotatory amlodipine which has relatively large side effects and no antihypertensive effect, the left-handed rotatory effect with antihypertensive effect and relatively small side effects was retained. 3. The dosage of amlodipine besylate and levamlodipine besylate Theoretically, a dose of 2.5 mg of L-amlodipine can achieve the antihypertensive effect of 5 mg of ordinary amlodipine mixed with racemate. Studies have shown that L-Amlodipine besylate 2.5mg and Amlodipine besylate 5mg have similar antihypertensive effects. The total effective rates of the two drug treatments were 84.91% and 77.45%, respectively. Amlodipine besylate usually has a starting dose of 5 mg once daily for the treatment of hypertension, and a maximum dose of 10 mg once daily. For small, weak, elderly, or patients with liver dysfunction, the initial dose is 2.5mg, once a day; this dose can also be the dose of this product combined with other antihypertensive drugs. The initial dose of L-amlodipine besylate in the treatment of hypertension is 2.5 mg once a day; according to the clinical response of the patient, the dose can be increased to a maximum of 5 mg once a day. The dose adjustment of the two drugs should be based on the individual patient response. The general dose adjustment should be started after 7-14 days. But emphasized that this is only theoretical, all blood pressure must be based on reality, the experience of many cardiovascular doctors is that 2.5mg amlodipine besylate can not completely replace 5mg amlodipine besylate. 4. Adverse effects of two drugs: Theoretically speaking, the side effects of levamilodipine are lower, but both drugs have side effects, and there is no specific comparison of which side effects are smaller. Common side effects of amlodipine besylate: the most common adverse reactions headache and edema, face flushing, palpitations; even nausea, fatigue, abdominal pain, drowsiness, etc. Common side effects of L-amlodipine besylate: headache, edema, fatigue, insomnia, heart, abdominal pain, flushing, palpitations, dizziness, etc. It should be pointed out that there are more detailed and various adverse reactions in the instruction manual. Let’s talk about this problem again. All rigorous drugs have undergone large-scale and rigorous clinical trials, even if one adverse reaction occurs globally in the trial. It must be documented and must be written in the instructions, this is just a rigorous performance. On a certain level, the more adverse reactions to the instructions, the more rigorous the medicine. Let’s think about the many drugs that we usually buy. Is it really unknown, or is it not recorded at all, or does not want to record at all. Therefore, the side effects and adverse reactions of the instructions are just for reference, no need to make any fuss. If you read the instructions of the western medicine, you will not take any medicine. In short, whether you are taking