Xiebeilu: Thymylase can be used as a diagnosis basis for myelodysplastic syndrome

Xiebeilu studio WeChat add369456 Myelodysplastic syndrome (MDS) is a clinical clonal hematopoietic stem cell disease, which is characterized by morbid or ineffective hematopoiesis of one or more lines of myeloid cells, decreased blood cells, and high-risk conversion to leukemia. The disease is a common clinical blood system disease, which is more common in the elderly. The cause of the disease is still unclear. Some people are exposed to ionizing radiation, strong electromagnetic fields, and organic solvents for a long time. The clinical manifestations of MDS patients mainly depend on blood cell abnormalities, usually anemia is the clinical sign, but many other diseases such as megaloblastic anemia (MA), aplastic anemia (AA. Hemolytic anemia, etc. have similar signs. Serum Thymidine kinase 1 (TK1) is closely related to cell proliferation, and its concentration can reflect the proliferation characteristics of normal cells and tumor cells. Lactate dehydrogenase (LDH) is an important glycolytic enzyme in hematopoietic cells, and the normal population only contains A small amount of LDH, when the human cells are damaged, the LDH content increases, clinically can be seen in diseases such as acute myocardial infarction, acute leukemia malignancies, hemolytic anemia, etc. LDH content is low in normal humans, when the body cells are damaged Rapid increase. It has been reported that LDH is helpful for the diagnosis and differential diagnosis of anemia diseases. MDS is mainly due to the disordered gene expression of gene mutation enzyme protein, which leads to changes in blood cell biochemical metabolism, which causes in situ hemolysis of young red blood cells and pathological hematopoiesis of bone marrow, resulting in patients The life cycle is shortened, and the serum LDH concentration is increased. The AA patients are mainly due to the damage of hematopoietic stem cells or microenvironment, and the red pulp in the body is replaced by fatty marrow, resulting in the reduction of whole blood cells, which is completely different from the pathogenesis of MDS. The serum LDH concentration is normal. There is no obvious difference among the population, so serum LDH can be used as one of the indicators for differential diagnosis of anemia. Thymine nucleoside kinase (TK) is mainly divided into 2 different TK isozymes: TK1, TK2, of which TK1 is mainly in the human body It appears in proliferating cells, such as bone marrow, spleen, pleural effusion, and adipose tissue. It is mainly expressed by cytoplasm, and its concentration can express the proliferation status of cells. At the same time, TK1 is related to the mechanism of intracellular DNA. Abnormal proliferation kinetics markers, the concentration in patients with malignant tumors is twice that of healthy people, and its positive expression is related to the proliferative capacity of digestive tract tumors and lung cancer cells and malignant lymphomas are not sensitive to chemotherapy. With the DNA in malignant tumors Synthesis, tumor cells differentiate and proliferate in large quantities, resulting in increased TK1 levels, so TK1 can be used as an important indicator to monitor the occurrence, development and prognosis of tumor diseases. At the same time, relevant studies have shown that the serum TK1 concentration in tumor patients varies with the patient’s condition Remission decreases, so it can be used as a monitoring index for the clinical efficacy of cancer patients. In hematological malignant tumors, the detection of serum TK1 concentration can be used as a prognostic factor for judging lymphoma and leukemia. MDS is a malignant clonal disease of hematopoietic stem cells. A large number of malignant hyperplastic bone marrow hematopoietic stem cells in the bone marrow and other hematopoietic tissues of patients with this disease cause the increase of TK1 concentration, so serum TK1 can be used for differential diagnosis of MDS. The study found that the sensitivity and specificity of serum TK1 detection in the diagnosis of MDS Both the degree and accuracy are higher than that of LDH, indicating that serum TK1 has higher diagnostic value in MDS than serum LDH. Serum TK1 can be used as an important observation indicator for differential diagnosis of MDS, and it can be used in combination with LDH to differentially diagnose anemia disease. It is stated that the serum TK1 concentration in MDS patients is higher than that in L DH differential diagnosis has higher sensitivity and specificity, and can be used as MDS screening, auxiliary diagnosis and disease progression monitoring. It can be used in combination with LDH to differentially diagnose anemia.