Yesterday, a young man visited the clinic, although wearing a mask. But the height and the characteristics of the face and face exposed clearly told me that he is a patient with acromegaly. Sure enough, the examination opened by our experts the day before has come out. Pituitary tumor. He said wearing 44 shoes, his feet are still getting bigger, and he seems to be still tall. Acromegaly (large limbs) is a chronic progressive endocrine disease with a concealed onset. The course of disease may be several years or even more than 10 years when the patient is seen. The main cause of large limbs is excessive production of growth hormone (GH) in the body. More than 95% of patients with large limbs are caused by pituitary adenoma that secretes GH. Long-term excessive secretion of GH can cause excessive proliferation of soft tissues, bones and cartilage throughout the body, causing changes in face, hypertrophy of the hands and feet, thick skin, enlarged internal organs, bone and joint disease, and sleep apnea syndrome. In addition, the incidence of malignant tumors such as pituitary tumor compression symptoms, diabetes, hypertension, cardiovascular and cerebrovascular diseases, respiratory diseases, and colon cancer will also increase. These metabolic disorders and complications seriously affect the health and quality of life of patients, leading to Patient life is shortened. Delays in clinical diagnosis and treatment will significantly increase the incidence of these complications. Not only clinicians, everyone should pay attention to the unusual signs of growing hands and feet as adults and growing taller. Timely medical evaluation. Do early detection and early treatment.