Meniere disease

Ménière Disease (Ménière Disease), also known as Meniere syndrome or endolymphatic hydrops, is an ear-derived vertigo disease characterized by membranous labyrinth hydrops. The characteristic manifestation is repeated episodes of rotational vertigo, fluctuating sexy Acoustic hearing loss is often accompanied by tinnitus and/or ear fullness. The etiology is unknown and may be related to a variety of factors. The basic etiology: Meniere’s disease is mainly caused by imbalance in the production and absorption of endolymph. There are many related theories. Mechanical obstruction of endolymphatic vessels and dyssorption of endolymph. Any stenosis or obstruction in the longitudinal endolymphatic flow, such as endolymphatic sac dysplasia, congenital stenosis, thickening of inflammatory fibrosis, etc., may cause mechanical endolymphatic vessels Obstruction or dyssorption of endolymph, leading to hydrops in the labyrinth, this theory has been confirmed by animal experiments. Theory of immune response In recent years, a large number of studies have confirmed that the inner ear can receive antigen stimulation and produce an immune response. Antigens that enter the human inner ear in different ways or are produced by itself can stimulate immune active cells that gather around blood vessels, endolymphatic sacs and endolymphatic vessels to produce antibodies. The inner ear is stimulated by the antigen-antibody reaction, resulting in capillary dilatation, increased permeability, body fluids penetrating the labyrinth, and hypersecretion of the stria vascularis, especially the endolymphatic sac absorption function due to the deposition of antigen-antibody complexes, which can cause membrane Lost and stagnant water. Inner ear ischemia theory. Inner ear small vasospasm and autonomic nerve dysfunction can cause microcirculation disorders in the inner ear and endolymphatic sac, causing tissue hypoxia, metabolic disorders, increased endolymph osmotic pressure, and migration of fluid in the perilymph and blood to form Membrane labyrinth water.