To prevent osteoporosis, in addition to vitamin D, vitamin K should be added? How to see the doctor

Speaking of prevention and treatment of osteoporosis, many people think of calcium and vitamin D for the first time. They are like twins and often appear together in the treatment of osteoporosis, such as calcium carbonate D3 tablets and vitamin D2 calcium lactate tablets. Wait. But many people don’t know that in addition to these two nutrients, there is actually a nutrient behind it that also plays a very important position in the occurrence and development of osteoporosis, and that is vitamin K. Usually when I talk to patients in the hospital, I mention vitamin K supplementation. Many patients will be puzzled. Isn’t osteoporosis supplemented with calcium and vitamin D? What is vitamin K? Let’s analyze it today. The role of vitamin K in bone metabolism. Vitamin K is a fat-soluble vitamin. They have four brothers: K1, K2, K3, and K4. To be precise, the boss and second child are mainly involved in bone metabolism, namely vitamin K1 and vitamin K2. . In the bone tissue of the human body, there are three kinds of vitamin K-dependent proteins, namely osteocalcin, matrix gamma carboxyglutamate protein and periosteal protein. Among them, osteocalcin is the main non-collagen protein in the bone, and the most important protein. Osteocalcin can undergo gamma carboxylation under the mediation of vitamin K and combine with calcium and hydroxyapatite to promote bone tissue mineralization and regulate the activity of osteoblasts and osteoclasts. In addition, vitamin K2 can also affect the expression of osteoblast-related genes through another pathway that does not rely on gamma carboxylation, and increases the expression level of osteoprotegerin mRNA, accelerating the transformation of osteoblasts to osteocytes. Several randomized controlled trials have found that vitamin K can reduce bone loss and reduce the incidence of fractures. Therefore, vitamin K also plays an important role in the prevention and treatment of osteoporosis. How to supplement vitamin K? Japan clearly recommended in the 2011 osteoporosis prevention and treatment guidelines that the recommended daily intake of vitamin K is 250-300μg. There are two main sources of vitamin K in daily life, dietary supplementation and intestinal bacterial synthesis. Among them, vitamin K1 is widely found in green vegetables and animal organs, while vitamin K2 is mainly a metabolite of intestinal bacteria. According to the analysis results, the vitamin K1 content in green leafy vegetables is the highest, among which spinach, leeks and Chinese cabbage are the most. Therefore, patients with osteoporosis can eat as much of these vegetables as possible in their daily lives. This is also the safest and most effective way to supplement. In short, in the prevention and treatment of osteoporosis, do not neglect vitamin K. Its existence can make the treatment of osteoporosis more effective. References: [1] Zhang Yuelei, Ding Hao, Gao Youshui, et al. Research progress of vitamin K in bone metabolism[J]. Chinese Journal of Osteoporosis and Bone Mineral Diseases, 2015, 8(3): 251-255[2 ] OrimoH, NakamuraT, HosoiT, etal. Japanese2011guidelinesforprevention andtreatmentofosteoporosis-executivesummary[J]. ArchOsteoporos, 2012, 7:3-20. (Some of the pictures in the article originate from the network and the copyright belongs to the original author. I would like to express my gratitude to the picture author. If you find any infringement of your copyright, please contact me and I will delete it.)

Hemophiliacs: Will vitamin K increase blood clotting factors?

Patients who know vitamin K know that this vitamin is also called coagulation vitamin and has chlorophyllin biological activity. Because it is helpful for blood coagulation, many patients speculate whether it will help the condition. Relevant analysis is made below. Ps: Vitamin K includes several forms such as K1, K2, K3, and K4. Among them, K1 and K2 are naturally-occurring fat-soluble vitamins; while K3 and K4 are artificially synthesized and are water-soluble vitamins. The chemical properties of the four kinds of vitamin K are relatively stable, and can withstand acid and heat. There is little loss in normal cooking, but they are sensitive to light and are easily decomposed by alkali and ultraviolet light. Can vitamin K stop bleeding and improve the blood clotting factor for hemophilia? The liver needs the help of vitamin K when combining blood clotting factors 2, 7, 9, and 10, so factors 2, 7, 9, and 10 are called vitamin K-dependent factors. In the same way, the only factors that increase vitamin K are factors 2, 7, 9, and 10. But most people do not lack vitamin K. For example, patients with hemophilia will not significantly improve after application. Only patients with vitamin K deficiency will have a significant hemostatic effect. If you have any questions about this article or the disease, please feel free to follow us on WeChat and search more: xueyb120