Hu Guisheng: Why do patients with leukemia experience symptoms of bone pain?

Hu Guisheng assistant WeChat: dd326751 mentioned bone pain, many people may think of rheumatism or which joints on the body are wrong. The joint and bone pain caused by leukemia blood cancer cells infiltrating bones and joints can be diffuse pain in the limbs or back or can be limited to joint pain, which often leads to difficulty in movement. More than 1/3 patients have tenderness in the sternum. & nbsp. In addition to bone pain, leukemia can be accompanied by other symptoms. Prone to bruises, spotted bleeding, anemia, wheezing and dizziness during exercise, persistent fever infection, long-lasting infection, swollen lymph nodes, swollen gums, liver and splenomegaly, headache and vomiting, blood cancer cells penetrate into the central nervous system There are lumps in the skin, and there is water in the pericardium or pleural cavity. Leukemia must be treated early in the hospital for active treatment. & nbsp. The cause of bone pain caused by leukemia is that leukemia cells proliferate too quickly in the bone marrow, resulting in increased pressure of the bone marrow cavity and a large amount of infiltration of leukemia cells. & nbsp. It can be diffuse pain in the limbs or back, or it can be limited to joint pain. It often causes difficulty in movement and is easily misdiagnosed as osteomyelitis or rheumatism. Some patients have tenderness in the sternum. There are also mild and moderate hepatosplenomegaly, etc., severe cases have headache, vomiting, Xiang Qiang, papilledema, even convulsions, coma and other typical manifestations of increased intracranial pressure. & nbsp. Therefore, the treatment method is to reduce the number of leukemia cells and inhibit the proliferation of leukemia cells, that is, chemotherapy treatment. At this time, the application of analgesic drugs is poor, and it needs to be added with chemotherapy drugs to be effective. Because of the different types of leukemia, the treatment plan is also very different. The specific time and amount of drugs need to be individualized according to the patient’s disease type, age, body surface area, and basic body condition.

Case sharing | How to reverse erythema in patients with lupus? Treatment of primary disease is the key

Lupus erythematosus is an autoimmune disease. Facial erythema is caused by the characteristics of the disease. It is a specific skin lesion change of lupus, which is mainly related to inflammation and lesions of small blood vessels under the skin. Its treatment is mainly for the treatment of the primary disease of lupus. & nbsp. & nbsp. (The erythema is obvious on admission → the erythema completely disappeared before discharge, the condition is ideally controlled) Case Description Female, 32 years old, with arthralgia, fever, myalgia, skin erythema as the main manifestations, positive urine protein, blood Routinely shows low white blood cells, and immunological antibody spectrum shows a variety of autoantibodies positive. One week before admission, the patient’s skin erythema worsened, especially on the face and chest, accompanied by sore throat and joint pain. Examination: The patient had a red rash on the chest, multiple flaky erythema near the neck, mild itching, red papules and scars on the elbow joints after the healing of the rash, and the sternal and right knee joints can be touched under the size of mung bean Nodules, no local itching and tenderness. Pharyngeal congestion, clear breath sounds in both lungs, no dry and wet rales, no tenderness in both knees (+). Check anti-nuclear antibody 1: 3200, high titer, low complement C3. Diagnosis: Systemic lupus erythematosus Lupus nephritis upper respiratory tract infection The above patients had positive urine protein, after conditioning by traditional Chinese medicine, urine protein has turned negative. The patient’s anti-nuclear antibody 1: 3200, meanwhile, the skin has stubborn erythema, low complement, and joint pain. It indicates the condition of the disease. Immunoadsorption therapy is given to quickly remove cytokines in the blood, inhibit inflammatory reactions, and regulate the body’s immune state. To achieve the purpose of treating the primary disease. At the same time, it is taken orally with Chinese medicine for clearing away heat and detoxifying, cooling blood and removing plaques, combined with comprehensive treatment of Chinese medicine collapse, infrared irradiation, moxibustion and so on. Before discharge, the patient’s skin erythema subsided, sore throat and joint pain improved, and no other complaints were reported. Warm reminder: erythema in patients with lupus erythematosus is a manifestation of skin and mucous membrane damage. Some patients may take a long time for the rash to subside, but most patients can subside after the disease is controlled. In most cases, this rash can be completely resolved after effective treatment, without leaving scars or pigmentation. Typical butterfly-like erythema or erythematous erythema can usually disappear after a few days or weeks after effective treatment. What do you think of this? Welcome to leave a comment!