Review the birth of the first vaccine

If it is said that the world is following the most people, it may be the “progress of the new crown vaccine”. Even if it is a bit of progress, it will attract the attention of a considerable part of the world, if not all. At the latest World Health Assembly, President Xi Jinping promised on behalf of China that after the new crown vaccine was developed and put into use, it would serve as a global public product and make Chinese contributions to the availability and affordability of vaccines in developing countries. This commitment embodies the idea that mankind is in the same community of destiny. This makes us think about going through the history of the birth of the first human vaccine. From “Human Pox Vaccination” used in Asia and Africa to prevent smallpox; to “Human Pox Vaccination” introduced to Europe and the United States; from vaccinia prevention of smallpox to today’s very safe inactivated or inactivated vaccines and genetic vaccines are all human common wisdom. Contribution. 224 years ago, at about this time, on May 14, 1796, a British country doctor, Edward Jenner, vaccinated an 8-year-old child, James Phipps, with vaccinia virus. Less than two months later, on July 1, he inoculated the child with smallpox virus to check whether the child was immunized against smallpox. Dr. Edward Jenner succeeded! 8-year-old James Phipps was not infected by variola virus infection. Although it seems that this practice is full of risks and not in line with medical ethics today, this is indeed a historical fact of the birth of the vaccine. Looking back at history, you will feel the greatness of human creativity! The miraculous ability of the human body (the immune ability that was not originally born, as long as the vaccine gives a little hint, the body can learn to recognize and resist this type of virus)! And the brilliance of biological technology! Smallpox disease is caused by smallpox virus. This disease has been raging for thousands of years in humans. It has been recorded in the history of China and India. Even the mummy (not honorable) of the Egyptian pharaoh has left traces. In the four to five centuries BC, smallpox spread to Europe, and then the Europeans brought it to the Americas, where smallpox killed a large number of local indigenous peoples. 20% to 60% of infected people die, most survivors are scarred, and nearly one third are blind. Child mortality is higher, and almost all infected babies have died. When humans have no way to prevent smallpox, people already know that people who recover from this disease will not get sick again even if they are exposed to this disease again. Based on the results of this observation, there is “human pox vaccination”. That is, the scab formed by the collapse of the patient’s pustules, deliberately introducing smallpox virus into people who have never suffered from this disease. This method has been adopted in Asia and Africa, including my country. At that time, the wife of the British ambassador living in Constantinople (Istanbul, Turkey today), Mrs. Mary Wortley Montagu had smallpox and had scars on her face, so in 1718, she gave her The younger son was vaccinated with “human pox” and brought information about this technology back to Europe. The inoculation of human pox in the Americas was brought from Africa through the introduction of slaves. Among them, the famous one was the black slave of Onesimus. He taught his master CottonMather This method was used in the smallpox epidemic in Boston, USA, in 1721. Vaccination of “human pox: it can indeed confer immunity to the human body, but this method is very dangerous, with a mortality rate of 2%. After vaccination, it may also trigger a complete smallpox attack and may spread the infection to others. The vaccine we are talking about today is The use of dead smallpox virus to activate the human immune system. People generally attribute the invention of the vaccine to Edward Jenner, a British country doctor. Edward Jenner lived in the United Kingdom when he was a child. Gloucester, who successfully vaccinated himself with smallpox virus. He observed that female workers working on dairy farms have very mild symptoms after contracting vaccinia, which is caused by the vaccinia virus (vacca in Latin), and the vaccinia virus also affects smallpox. Immune. In fact, Edward Jenner is not the only one who notices this observation,