How does hydroxyurea treat polycythemia vera?

Polycythemia vera is a myeloid blood disease with an unexplained abnormal proliferation of red blood cells, and patients with true red are often accompanied by an increase in white blood cells and platelets, which also increases the risk of blood clots in the patient. &nbsp.What are the ways to treat true redness? Commonly used drugs for the treatment of true red are hydroxyurea, alkylating agents, interferon, homoharringtonine and so on. In addition to western medicine, patients can also choose Chinese medicine treatment, intravenous bloodletting, and red blood cell apheresis. The administration of hydroxyurea is relatively common. Let’s learn about the pathological problems of this drug in the treatment of true red. How does hydroxyurea treat true red? Let’s first understand the incidence of this disease. True red patients are usually accompanied by JAK2 gene mutations. What is the JAK2 gene? ——JAK2 gene belongs to the JAK gene. STAT is phosphorylated and enters the nucleus to regulate the gene expression of the human body. This is the JAK-STAT pathway. After the patient’s JAK2 gene mutation, it will continue to activate the JAK-STAT pathway, leading to abnormal cell proliferation, apoptosis, and ultimately true redness. Hydroxyurea is a nucleoside diphosphate reductase inhibitor that can inhibit the reduction of RNA to DNA, and selectively hinder DAN synthesis, interfering with purine and pyrimidine base biosynthesis. At the same time, hydroxyurea also has an inhibitory function on bone marrow hematopoiesis, can effectively inhibit the production of red blood cells, platelets, and white blood cells, and play a role in treating true red. In the course of treatment with hydroxyurea, side effects such as vomiting, hair loss, and black nails will occur. Patients can choose symptomatic treatment to relieve the side effects. In addition, patients can also check relevant information in advance to learn as much as possible about the condition, so as to recover from the condition as soon as possible. For more patient communication help, please follow the WeChat public account [True Red Patient Club] zkxy120