The role of uNK is different from that of peripheral NK

Experimental animal models have always been the key to our understanding of how uNK cells function in maternal decidua. Especially animals that use maternal blood to directly contact the placental system of fetal tissues like humans, such as mice, rats, and guinea pigs. Research using these animals has special effects. This direct immersion of fetal villi into maternal blood allows for effective nutrient and gas exchange; however, doing so is likely to pose greater challenges to the maternal immune system. This is because placental cells penetrate the wall of the uterus and infiltrate the tissues. This is in contrast to the use of epithelial villi placenta in most species of animals, that is, trophoblast cells only sit on the epithelial surface. Mice lacking uNK cells showed normal implantation sites, suggesting that these cells play a key role not at this very early stage. In mice, uNK cells produce several substances that seem to be useful in promoting healthy placenta formation after successful implantation, such as vascular endothelial growth factor (VEGF) and gamma interferon. As shown in the pregnant mouse model, gamma interferon is a key promoter of spiral artery remodeling in the decidua, but an important difference between mice and humans is that human uNK cells do not produce large amounts of gamma interferon. This species difference always needs to be considered. Despite the lack of a reliable trophoblast cell invasion model in vitro, this process seems to be regulated by the production of interleukin-8 and interferon-induced protein 10 chemokines (tobeorchestrated). However, more relevant is the human genetic data. These data provide evidence that mothers with a set of KIR genes encoding activating receptors are less likely to suffer from pregnancy placental diseases such as threatened epilepsy. The soluble cytokines and chemokines produced by uNK suggest that uNK is critical in supporting normal human pregnancy, although it is still unclear how to perform this process precisely. So far, there is no convincing evidence suggesting that uNK has killed placenta or fetal cells. When it is isolated from the uterus and challenged in vitro (challengedinvitro), these cells have poor ability to kill target cells, only in interleukins. 2 It has a cytotoxic effect when it is present, and there is no interleukin 2 in the human uterus under normal conditions. Thus, at present, there is no absolute scientific basis to suggest that uNK needs to be inhibited.

Can keloids be screened in advance?

Not long ago, the Journal of Cosmetic Dermatology published an article in which the author studied the correlation between serum interleukin 37 (IL-37) and keloids. Keloid is a dermal fibroproliferative disease characterized by excessive deposition of extracellular matrix components. IL-37 reduces the production of extracellular matrix by inhibiting transforming growth factor (TGF), thereby inhibiting the proliferation of keloid fibroblasts. Therefore, IL-37 can be used for early prevention and treatment of keloids. &nbsp. Through the analysis of clinical sample data, the author finally believes that IL-37 levels are negatively correlated with the severity of keloids. In addition, the IL-37 levels of keloid patients are not significantly correlated with age, gender, duration of lesions, and family history. Sex. If it is proved that the reduction of IL-37 level is sufficient and necessary for the formation or aggravation of keloids, can people with a history of keloids be able to judge or prevent keloids by detecting the level of serum interleukin 37? The answer is uncertain, but as more research is carried out, we will learn more about keloid scars.

How to treat condyloma acuminatum

Condyloma acuminatum is caused by the papilloma virus, which is easy to grow and reproduce in a warm, humid and cold natural environment, so the reproductive organs are its suitable location. Very few people get infected by touching the daily necessities, such as underwear, bathtubs, towels, etc., that are polluted by virus-infected particles. To reduce the body’s immunity and antiviral treatment ability, it is necessary to apply antiviral treatment to improve its own immune ability.   1. Medication treatment. Appropriate medicines should be used to treat the wounds of patients, and the skin of condyloma acuminatum should be constantly wiped with medicines, so that the hpv antigen in the skin is exposed to the human immune system in the cowhide, so as to create and give full play to the detailed immunity Function to eliminate wart bodies.  2. To eliminate the mechanism of genital warts, it is a basic step to visualize. The methods used are external application therapy, such as refrigeration, laser, microwave heating, electric burning and other physical therapy methods and surgical treatment.  3. Improve the patient’s immunity. This step is considered important. If the patient’s immunity is improved, the disease will be eliminated. To improve the patient’s ability to resist hpv, the method used is systemic or reversible immunotherapy. If interferon is used to treat condyloma acuminatum, it can be used in conjunction with other methods, or interferon can be used after the wart is removed by other methods to exceed the purpose of auxiliary treatment or to reduce the attack. However, the incidence of side effects of interferon is relatively high. Interleukin is a class of substances caused by damage to biological cells, and is the main manifestation of the body’s defense. The interleukin-2 used in the treatment of condyloma acuminata is a glycoprotein produced by active T lymphocytes and has a certain auxiliary effect on reducing seizures.

MDS group: “Relidamide” mainly has these seven points!

“Lelidomide”-This drug has the effect of inhibiting the proliferation of malignant cloned cells and promoting their apoptosis in clinical medical applications, and has a certain effect evaluation on MDS. The main functions are the following seven points! 1. Inhibit tumor necrosis factor a; 2. Interleukin-6 and IL-123, induce Caspase-8-mediated apoptosis; 4. Inhibit cell adhesion and angiogenesis; 5. By inducing interleukin-2; 6. Interferon г Stimulates the proliferation of T and NK cells; 7, inhibits Akt phosphorylation, etc.; … This drug has therapeutic value for MDS, but it also has drawbacks. Sufficient attention needs to be paid to safety to avoid affecting the quality of life of patients and the high risk of complications. To learn more about “disease knowledge” or “MDS patient group communication” and other WeChat search public number: gsby120

How to avoid the side effects of taking androgens in female patients with aplastic anemia?

Shi Shurong’s studio WeChat xyk261 androgen is a traditional Chinese medicine for the treatment of aplastic anemia. It stimulates the kidney to produce erythropoietin, promotes erythropoiesis and promotes granulocytes and platelets. Studies have shown that the bone marrow hematopoietic failure of AA is mainly related to activated cytotoxic T cells, and the activation and proliferation of CIL. Is mainly limited to the target organ of bone marrow. The mechanism of action of CsA in treating aplastic anemia can be roughly summarized as follows: 1. Regulation of T cells; the proportion of subpopulations; 2. Inhibition of the expression of interleukin-I receptors by T cells, the production of interleukin-I and the responsiveness of T cells to interleukin-I; 3. Inhibits the negative regulation of hematopoiesis by T cells producing γ-interferon, tumor necrosis factor and interleukin-I; 4. Indirectly improves CFU-GM growth. However, the drug has various degrees of toxic and side effects such as liver damage, hairiness, acne, and virilization characteristics. Although immunosuppressive agents have a certain effect in the treatment of aplastic anemia, the adverse reactions are greater. Chinese medicine has a certain effect on the treatment of aplastic anemia, and it has little toxic and side effects. Although there are reports of traditional Chinese medicine treatment of aplastic anemia, the treatment is different, the standard treatment plan is lacking, and the number of clinical observation cases is relatively small. In this study, Shengxue Mixture with spleen, kidney and blood circulation was used to treat aplastic anemia, and its clinical efficacy was observed. The pathogenesis of aplastic anemia is not only the deficiency of the spleen and kidney, but also the pathological changes of the deficiency and spleen. The deficiency of the spleen and kidney can cause stasis of blood stasis, which is called “deficiency and long stasis”. The organs of the organs can not get the normal nutrition and warmth of the nutrients, and it also increases the deficiency of the organs. This vicious circle of stasis due to deficiency and stasis due to stasis can aggravate the condition of aplastic anemia. In this regard, governance should be blood circulation, blood circulation, blood circulation to stop bleeding. Blood stasis is gone, new blood is born. Shengxue Mixture starts with strengthening the spleen and kidney, and is equipped with medicine for purging fire and cooling blood, and promoting blood circulation and removing blood stasis. Its basic prescription is astragalus, codonopsis pilosula, qi and qi, mature virgin sage, psoralen, dodder and kidney filling and filling: Zuodanshenhuoxue nourishes blood, functions and four things, invigorates blood, removes blood stasis and produces new, fried peony skin cool Xuexiehuo, Huoxue Sanyu: Licorice to reconcile various medicines. Compound saponin pills are currently used in the clinical treatment of chronic aplastic anemia, and are composed of saponin, American ginseng, hippocampus, and other medicines. Saponin contains more than 10 trace elements, of which iron, copper, and cobalt are essential raw materials for hematopoiesis. This medicine has the function of strengthening bone marrow and producing blood, and is believed to increase bone marrow hematopoietic cells; promote the proliferation of bone marrow microcirculation. Compound Zaofan Pills combined with Anxiong are more effective in treating chronic aplastic anemia. In this study, compound saponin pills combined with Anxiong were used as controls to evaluate the clinical efficacy of Shengxue Mixture combined with low-dose androgen in the treatment of chronic aplastic anemia. The results showed that the treatment plan had significant efficacy and few side effects. It shows that the comprehensive plan composed of the method of strengthening the spleen and kidney and promoting blood circulation combined with low-dose androgen is an effective treatment for chronic aplastic anemia.

Banzhilian ointment for the treatment of HPV positive condyloma acuminatum scientific research results passed the identification

People’s Network · Tianjin Windows, January 14th: The reporter recently learned from the Fifth Central Hospital of Tianjin that the self-researched semi-twisted external coating of the hospital’s dermatology department and interleukin Ⅱ to prevent HPV-positive genital warts recurrence project obtained Tianjin Science Identification of technical achievements. Jia Siyou, deputy chief physician of the Department of Dermatology and Venereology at Tianjin Fifth Central Hospital, the main person in charge of the project, said that cervical HPV-positive condyloma acuminatum is a common disease for STDs, accounting for 25% of the total number of outpatient cases, and it is a frequent occurrence. We studied the use of Banzhilian and interleukin Ⅱ to prevent the recurrence of cervical HPV-positive condyloma acuminatum, and found that it has a certain effect through clinical practice. On the one hand, it can relieve the patient’s pain, on the other hand, it can reduce the patient’s financial and psychological burden, while shortening the course of the disease, and also adds a means to prevent relapse. (Intern Meng Wei) Disclaimer [Image]