Can interferon really cure human papillomavirus?

   Human papillomavirus is the main virus that causes condyloma acuminatum, which is very harmful to oneself and family members. As one of the common venereal diseases in society today, there are many treatment methods for human papillomavirus, interferon is one of the more common treatment methods. Li Xingchun pointed out: Interferon is an antiviral drug, which can only inhibit the replication of pathogens and relieve the surface symptoms, but cannot completely remove the human papillomavirus in the deep layers of the skin. Once the drug is stopped, symptoms will appear quickly, and more medicinal use , There will be fever, headache and other symptoms, which will damage the liver and kidneys to a certain extent. Therefore, for patients who choose interferon to treat human papillomavirus, they must comprehensively analyze their own situation, weigh the pros and cons and not blindly use drugs. Interferon [Expert Analysis]: Four major side effects of interferon 1. It can cause other symptoms: fever, nausea, fatigue, dizziness, headache and other symptoms similar to fever may occur within 2-5 hours after intramuscular injection of interferon , The body temperature can be as high as 38℃-40℃, and the symptoms disappear after 24 hours.  2. It can affect the digestive function of patients: Interferon can also affect the digestive tract function of human papillomavirus patients, causing patients to experience nausea, vomiting, greasiness, loss of appetite, abdominal distension and abdominal pain.  3. Can cause hematopoietic abnormalities: Long-term interferon therapy can also inhibit the bone marrow tissue of patients with human papillomavirus, reducing the content of platelets and white blood cells in the blood, causing hematopoietic abnormalities.  4. It can cause different levels of hair loss: generally after 3 months of interferon treatment, human papillomavirus patients will experience varying degrees of hair loss, and more serious patients may have mild skin rashes. Recombinant human interferon experts remind: Although interferon treatment of human papillomavirus can control the development of the disease in the short term, it can also treat the damage of subclinical infection, but it cannot remove the virus lurking deep in the skin. It can bring a burden to the body, produce drug resistance, and lead to repeated illnesses. Therefore, the treatment of human papilloma virus must not be blindly treated, and the treatment should be based on the patient’s own condition. Reprint please indicate: Nanjing Institute of gifted Ka medical wart virus Lixing Chun, otherwise declined to reprint.

Real red patients playing interferon emphasize two points: liver protection and adverse reactions!

Polycythemia vera is a kind of myeloproliferative disease and a hematological malignancy. It is manifested as the continuous increase of red blood cells, often accompanied by increased white blood cells and platelets. However, the development of the disease is slow and the course of the disease is long, which can last for more than 10 years or even longer. To treat true red, pay attention to these three points: 1. Control the number of red blood cells. Interferon is commonly used and can also be supplemented by other oral chemotherapy drugs. 2. To control the tendency of thrombosis caused by the increase of red blood cells, you can take aspirin and other anticoagulant and blood stasis drugs. 3. If the disease is to be cured, the only way is allogeneic hematopoietic stem cell transplantation. Note for patients who choose interferon: ①&nbsp. You can follow the doctor’s advice and add hepatoprotective drugs at the same time, because this drug hurts the liver. ②&nbsp. When interferon is given, the first three injections usually respond, showing fever, muscle and joint pain, and you can take it orally in advance Sanlitong relieves symptoms. When interferon is used to treat this disease, the usual dose is 3 million units, subcutaneously injected once a day, and then gradually reduced according to the number of red blood cells to a long-term maintenance amount. For more patient communication help, please follow the WeChat public account [True Red Patient Club] zkxy120

The role of uNK is different from that of peripheral NK

Experimental animal models have always been the key to our understanding of how uNK cells function in maternal decidua. Especially animals that use maternal blood to directly contact the placental system of fetal tissues like humans, such as mice, rats, and guinea pigs. Research using these animals has special effects. This direct immersion of fetal villi into maternal blood allows for effective nutrient and gas exchange; however, doing so is likely to pose greater challenges to the maternal immune system. This is because placental cells penetrate the wall of the uterus and infiltrate the tissues. This is in contrast to the use of epithelial villi placenta in most species of animals, that is, trophoblast cells only sit on the epithelial surface. Mice lacking uNK cells showed normal implantation sites, suggesting that these cells play a key role not at this very early stage. In mice, uNK cells produce several substances that seem to be useful in promoting healthy placenta formation after successful implantation, such as vascular endothelial growth factor (VEGF) and gamma interferon. As shown in the pregnant mouse model, gamma interferon is a key promoter of spiral artery remodeling in the decidua, but an important difference between mice and humans is that human uNK cells do not produce large amounts of gamma interferon. This species difference always needs to be considered. Despite the lack of a reliable trophoblast cell invasion model in vitro, this process seems to be regulated by the production of interleukin-8 and interferon-induced protein 10 chemokines (tobeorchestrated). However, more relevant is the human genetic data. These data provide evidence that mothers with a set of KIR genes encoding activating receptors are less likely to suffer from pregnancy placental diseases such as threatened epilepsy. The soluble cytokines and chemokines produced by uNK suggest that uNK is critical in supporting normal human pregnancy, although it is still unclear how to perform this process precisely. So far, there is no convincing evidence suggesting that uNK has killed placenta or fetal cells. When it is isolated from the uterus and challenged in vitro (challengedinvitro), these cells have poor ability to kill target cells, only in interleukins. 2 It has a cytotoxic effect when it is present, and there is no interleukin 2 in the human uterus under normal conditions. Thus, at present, there is no absolute scientific basis to suggest that uNK needs to be inhibited.

How does interferon treat essential thrombocythemia?

The first-line drugs for the treatment of essential thrombocythemia are commonly hydroxyurea and interferon. Among them, interferon is mostly used for patients under the age of 40. So how does interferon treat thrombocytosis? Interferon treatment of thrombocytosis: Interferon is a cytokine that has many functions such as inhibiting cell division, regulating immunity, anti-virus and anti-tumor. Because interferon can inhibit megakaryocyte production and shorten the survival time of platelets. Therefore, interferon is also widely used in the treatment of thrombocytosis. Common interferon is usually administered by subcutaneous injection, three times a week or once every other day, the recommended dose is 3~5MU, and the course of treatment is generally 6 months. After onset of effect, the dosage and course of treatment can be adjusted appropriately according to the patient’s condition and tolerance to the drug. For patients treated with pegylated interferon [α-2a], it is recommended to inject 180μg subcutaneously once a week for one year; for patients with pegylated interferon [α-2b], it is recommended to inject 1 per week The dose is 1.0-1.5μg/kg, and the course of treatment is one year. The dosage and course of treatment of specific drugs should be appropriately adjusted according to the actual situation. Experts remind: In the early treatment process, it is recommended that patients be followed up regularly and blood routine check once a week in order to grasp the changes in the condition in real time and adjust the treatment plan in time. For patients with poor interferon treatment, it is necessary to promptly report back to the doctor, change to other treatment plans or take a combination of drugs to relieve. For more patient communication help, please pay attention to the WeChat public account [thrombocytosis patients association] xxbzd999

[Doctor-patient question and answer] How to alleviate the side effects of interferon combined with hydroxyurea treatment?

Patient consultation: Hello doctor, I am a patient with thrombocytosis. Due to the high platelet count, in addition to oral hydroxyurea tablets, interferon therapy is also used. The treatment effect is remarkable. My platelets have dropped from the original 1300 to 560, but my body has reacted a lot after I was given interferon recently. The main symptoms are dizziness, low-grade fever and leg muscle pain. These side effects have a great impact on my life. What should I do? Expert advice: After the diagnosis of essential thrombocythemia, routine blood tests often find that the number of platelets is 1000—3000X10^9/L. Essential thrombocythemia is a myeloproliferative disease, the bone marrow picture is dominated by megakaryocytes and platelet proliferation. Hemorrhagic thrombocytosis caused by cloning of hematopoietic stem cells, the main clinical symptoms are fatigue, fatigue, thrombocytosis, splenomegaly, and bleeding or thrombosis. Hydroxyurea and interferon treatment of thrombocytosis will produce different degrees of side effects, such as dizziness, fever and fatigue. If there is obvious discomfort, you can communicate with the doctor to change the [treatment method] or reduce the dose to relieve the symptoms. In addition to hydroxyurea and interferon, platelet apheresis, aspirin and other drugs with anti-platelet aggregation can also be selected for treatment. Thrombocythemia progresses relatively slowly and can maintain a benign process for many years. However, if the treatment is not active, there is a risk of turning into acute leukemia in the later stage. Therefore, patients should improve treatment compliance, regularly check blood routines, and observe changes in their condition. For more patient communication help, please pay attention to the WeChat public account [thrombocytosis patients association] xxbzd999

What should patients pay attention to during the treatment of polycythemia vera?

Although the onset of polycythemia vera is insidious, it is not without symptoms at all, but the symptoms have no obvious directionality and are easily ignored by the patient as a general disease. True red patients are prone to “drunk appearance” due to high red blood cell and hemoglobin counts in the body, that is, redness of the skin, and some patients will also experience symptoms such as skin itching, tinnitus and vertigo. In fact, true red is a malignant hematological disease. If you do not pay attention to the treatment of the natural course of the disease, there are only a handful-then what should patients pay attention to during the treatment of polycythemia vera? ①&nbsp. If you want to control the number of red blood cells, you can use interferon or other oral chemotherapy drugs. ②&nbsp. To control the tendency of thrombosis caused by the increase of red blood cells, it is recommended to take aspirin and other anticoagulant and blood stasis drugs. ③&nbsp. If you want a long-term stable condition, you need a combination of Chinese and Western treatment. For patients with true red who started to inject interferon therapy, the time and dosage of the medication must be in accordance with the doctor’s advice, and at the same time, take measures to deal with side effects: ①&nbsp. While using interferon treatment, pay attention to adding liver protection drugs at the same time to prevent long-term medication Cause liver disease; ②&nbsp. When interferon is injected, the first three injections generally respond, showing fever, muscle and joint aches, and oral Sanlitong can be added in advance to relieve symptoms. ③Treat red patients who were treated with interferon in the early stage also cooperated with Chinese medicine and traditional Chinese medicine to help patients achieve better treatment results. As the course of true red disease progresses, not only will the symptoms become more obvious, but the harm will also become greater. True red may develop into leukemia in the later stage. Therefore, in order to prevent the transformation of true red to a more serious disease, patients should be actively treated after diagnosis, and try to control the disease as early as possible. For more patient communication help, please follow the WeChat public account [True Red Patient Club] zkxy120

The new drug for polycythemia vera, the two-year evaluation result of alfa-2b is “released”!

Polycythemia vera (PV) is a clonal chronic myeloproliferative disease of hematopoietic stem cells. PV starts insidiously and progresses slowly, and usually goes through the following two stages of progression: ① Proliferation or polycythemia phase-often with erythrocytosis; ② Late erythrocytosis-manifested as pancytopenia, extramedullary hematopoiesis, liver and spleen Large, hypersplenism and bone marrow fibrosis. The new drug for polycythemia vera, the two-year evaluation result of alfa-2b is “released”! What kind of medicine is this? This drug is a new single-isomer long-acting peginterferon in the clinical development stage for the treatment of patients with polycythemia vera (PV). Last year, in 2018, there was a 36-month progress result of this drug, which concluded that this drug has a good control effect and good tolerability. It makes medical practitioners more convinced that this drug will be a new generation of “interferon” (more knowledge comes from the bottom right of the picture). The beneficial result of this drug in the treatment of true red (the result of two-year evaluation) is released: • It can reflect better The advantages of available therapies; • Complete blood response rate and long-term clinical and blood response rate can be achieved; • Two-year safety and drug resistance are reflected; • The ability to relieve the disease has been further proved;… I hope that the popularization of new drugs can really benefit patients, so that every patient can see the onset of illness! Learn more about “disease knowledge” or “blood patient group communication” and other WeChat search public number: xejb120

What should patients pay attention to during the treatment of polycythemia vera?

Although the onset of polycythemia vera is insidious, it is not without symptoms at all, but the symptoms have no obvious directionality and are easily ignored by the patient as a general disease. True red patients are prone to “drunk appearance” due to high red blood cell and hemoglobin counts in the body, that is, redness of the skin, and some patients will also experience symptoms such as skin itching, tinnitus and vertigo. In fact, true red is a malignant hematological disease. If you do not pay attention to the treatment of the natural course of the disease, there are only a handful-then what should patients pay attention to during the treatment of polycythemia vera? ①&nbsp. If you want to control the number of red blood cells, you can use interferon or other oral chemotherapy drugs. ②&nbsp. To control the tendency of thrombosis caused by the increase of red blood cells, it is recommended to take aspirin and other anticoagulant and blood stasis drugs. ③&nbsp. If you want a long-term stable condition, you need a combination of Chinese and Western treatment. For patients with true red who started to inject interferon therapy, the time and dosage of the medication must be in accordance with the doctor’s advice, and at the same time, take measures to deal with side effects: ①&nbsp. While using interferon treatment, pay attention to adding liver protection drugs at the same time to prevent long-term medication Cause liver disease; ②&nbsp. When interferon is injected, the first three injections generally respond, showing fever, muscle and joint aches, and oral Sanlitong can be added in advance to relieve symptoms. ③Treat red patients who were treated with interferon in the early stage also cooperated with Chinese medicine and traditional Chinese medicine to help patients achieve better treatment results. As the course of true red disease progresses, not only will the symptoms become more obvious, but the harm will also become greater. True red may develop into leukemia in the later stage. Therefore, in order to prevent the transformation of true red to a more serious disease, patients should be actively treated after diagnosis, and try to control the disease as early as possible. For more patient communication help, please follow the WeChat public account [True Red Patient Club] zkxy120

Does thrombocytosis need long-term injection of interferon?

Nowadays, the treatment of thrombocytosis in western medicine is mostly oral hydroxyurea and interferon. But we all know that the side effects of western medicine treatment are obvious. Patients treated with interferon reported that after the injection, they always felt muscle aches, fever, and dizziness. Therefore, many patients are very concerned, do I need to always inject interferon to treat this disease? Thrombocytosis is a disease of abnormal myeloproliferation, often manifested as a high platelet count in the peripheral blood. Because the cause of this disease is not clear and the condition is easy to recur, most patients need long-term or lifelong treatment to prevent the development of the disease and endanger the life of the patient. How to relieve the side effects of interferon? If the patient has side effects such as nausea and vomiting and poor sleep quality during the treatment, symptomatic treatment can be used to relieve it. In addition, patients can also add traditional Chinese medicine treatment to increase efficiency and reduce harm, relieve patients’ discomfort and symptoms, but also improve efficacy. Long-term injection of interferon has great side effects. If the patient has serious discomfort, he should actively communicate with the doctor to clarify the condition and determine whether it is necessary to change the medication or reduce the dosage to alleviate the impact of side effects. In addition to active treatment for patients with thrombocytosis, they should also pay attention to the prevention of bleeding tendency and thromboembolism in their daily life. These two symptoms are very dangerous for patients, especially middle-aged and elderly people. The formation of thrombosis will shorten the life of the patient or directly lead to it. The patient died. For more patient communication help, please pay attention to the WeChat public account [thrombocytosis patients association] xxbzd999

Beware of interferon side effects! How often do you check blood routines for thrombocytosis?

The treatment of thrombocytosis often uses hydroxyurea, interferon, aspirin and other drugs. Among them, interferon is mostly used in patients under the age of 40, so what should patients with thrombocytosis pay attention to when using interferon treatment Aspect? Beware of interferon side effects! How often do you check blood routines for thrombocytosis? ——Interferon is a cytokine, and some side effects will occur during the treatment. Note: The systemic reaction mainly manifests as flu-like symptoms, namely chills, fever, and discomfort; some patients with local reactions may have erythema and tenderness at the injection site ; Other hair loss, skin rash, rapid erythrocyte sedimentation rate, lethargy, liver damage. Occasionally anaphylactic shock. ——Interferon treatment of thrombocytosis, patients should check blood routine regularly: ①&nbsp. Once a week in the first month of treatment; ②&nbsp. Once every two weeks in the second month, and once a month thereafter; ③&nbsp. Once stabilized every 3 months. Some patients may have psychiatric symptoms such as hypothyroidism and depression after using interferon. Therefore, thyroid function tests should be performed before using interferon, and the patients should be carefully asked whether they have a history of mental illness. Thrombocytosis is a kind of abnormal proliferation of bone marrow. The disease progresses to the later stage and may develop in the direction of leukemia. Therefore, no matter which treatment method you choose, you must actively cooperate to control the condition as soon as possible and avoid the development of the disease. For more patient communication help, please pay attention to the WeChat public account [thrombocytosis patient association]xxbzd999

[Doctor-patient question and answer] Why did the white blood cell count drop after true red interferon treatment?

Patient question: Hello doctor, after I was diagnosed with polycythemia vera recently, I started to take interferon for treatment. But in the process of treatment, I always feel weak. After going to the hospital to review the blood routine, it was found that the white blood cells were reduced. Is it because of interferon? Does the lowered blood picture mean that my condition is getting worse again? Doctor’s answer: Polycythemia vera is a myeloproliferative disease. Interferon and other drugs are used to inhibit abnormal erythrocytosis. Myelosuppression is not targeted, and it will inevitably involve the simultaneous decline of platelets and white blood cells. Although the above phenomenon is normal, a significant decrease in the number of white blood cells or platelets may bring other harmful manifestations to the patient, and even further endanger health. Therefore, when encountering such a situation, it is necessary to appropriately adjust the dosage of the medicine according to the doctor’s advice, so that it can control the red blood cells without having too much influence on the platelets and white blood cells. However, it should be noted that some patients have no effect on drug adjustments and continue to “drop blood”. At this time, try to change the treatment plan. In addition to oral hydroxyurea, melphalan and other drugs, you can also cooperate with targeted drugs to gradually increase the blood picture and relieve side effects And reduce the occurrence of complications. For more patient communication help, please follow the WeChat public account [True Red Patient Club] zkxy120

How to treat condyloma acuminatum

Condyloma acuminatum is caused by the papilloma virus, which is easy to grow and reproduce in a warm, humid and cold natural environment, so the reproductive organs are its suitable location. Very few people get infected by touching the daily necessities, such as underwear, bathtubs, towels, etc., that are polluted by virus-infected particles. To reduce the body’s immunity and antiviral treatment ability, it is necessary to apply antiviral treatment to improve its own immune ability.   1. Medication treatment. Appropriate medicines should be used to treat the wounds of patients, and the skin of condyloma acuminatum should be constantly wiped with medicines, so that the hpv antigen in the skin is exposed to the human immune system in the cowhide, so as to create and give full play to the detailed immunity Function to eliminate wart bodies.  2. To eliminate the mechanism of genital warts, it is a basic step to visualize. The methods used are external application therapy, such as refrigeration, laser, microwave heating, electric burning and other physical therapy methods and surgical treatment.  3. Improve the patient’s immunity. This step is considered important. If the patient’s immunity is improved, the disease will be eliminated. To improve the patient’s ability to resist hpv, the method used is systemic or reversible immunotherapy. If interferon is used to treat condyloma acuminatum, it can be used in conjunction with other methods, or interferon can be used after the wart is removed by other methods to exceed the purpose of auxiliary treatment or to reduce the attack. However, the incidence of side effects of interferon is relatively high. Interleukin is a class of substances caused by damage to biological cells, and is the main manifestation of the body’s defense. The interleukin-2 used in the treatment of condyloma acuminata is a glycoprotein produced by active T lymphocytes and has a certain auxiliary effect on reducing seizures.

How can treatment be effective to prevent thrombosis in patients with thrombocytosis?

The purpose of treatment for patients with thrombocythemia is not only to lower platelet counts, but more importantly to prevent bleeding and thrombosis. Especially for middle-aged and elderly patients, the formation of thrombosis can directly endanger life and health. So what is the effective way to treat thrombocytosis? There are four commonly used and effective methods for the treatment of thrombocytosis: 1. Hydroxyurea: Patients treated with hydroxyurea should undergo routine blood monitoring: once a week for the first 2 months of treatment, once a month afterwards, and every time after the blood picture is stable. Once every 3 months. Patients who are resistant or intolerant to hydroxyurea can switch to second-line drugs such as interferon or aragrelide. 2. Interferon: It is the first choice for the treatment of patients under 40 years old. However, some patients may experience psychiatric symptoms such as hypothyroidism and depression after using interferon. Therefore, thyroid function tests should be performed before using interferon, and the patients should be carefully asked whether they have a history of mental illness. 3. Platelet separation: quickly reduce the number of platelets and improve symptoms. It is often used for gastrointestinal bleeding, pregnancy and childbirth, and before elective surgery. 4. Others: such as dipyridamole, aspirin, and indomethacin can prevent platelet aggregation. Patients with thrombosis should use heparin or double coumarin anticoagulants. Spleen cutting is contraindicated. The first choice for the treatment of thrombocytosis is hydroxyurea. Because of the long course of thrombocytosis, patients often need long-term medication. However, the side effects caused by hydroxyurea cannot be ignored, so patients can take symptomatic treatment to alleviate adverse reactions, or add Chinese medicine to cooperate with treatment at the right time, which can effectively alleviate the side effects of chemotherapy drugs. For more patient communication help, please pay attention to the WeChat public account [thrombocytosis patients association] xxbzd999

Is interferon effective in treating condyloma acuminatum?

Physiotherapy: There are many ways of physical therapy. Patients can choose suitable physical therapy methods according to their own characteristics of condyloma acuminatum. For example, if the total number of condyloma acuminatum is small and the total area is small, then it is generally possible to choose refrigerated treatment, electric Cautery treatment; If the patient’s condyloma acuminata is multiple or large in total area, laser surgery can be selected; for extremely large condyloma acuminata, surgery is recommended to remove the patient’s warts completely or in stages. Interferon treatment: After the patient is successful in physical therapy, the patient can choose interferon to cooperate with each other to promote treatment under the specific guidance of the doctor, but remember that interferon cannot be used too much, and many applications of interferon will cause the patient Negative effects are not good for the physical and mental health of patients, and the dosage of interferon must be properly controlled. Common problems with patients’ diet matching: Patients should choose a light-tasting diet, but they should pay attention to improve their nutritional content, use more ingredients that contain protein and vitamins, and choose some fresh fruits in moderation, and eat more fresh ones. For fruits and vegetables, patients need to maintain adequate water. Patients should pay attention to eating less spicy food ingredients, less smoking and drinking, eating less starchy food ingredients, and doing moderate fitness exercises and exercises in daily life to enhance immunity.

Doctor Shi Shurong: In addition to hydroxyurea can treat thrombocytosis, what other treatments are there?

The most common drug for the treatment of thrombocytosis is hydroxyurea. Oral hydroxyurea tablets can control the number of platelets, the effect is better, and it can be taken for a long time. However, while treating with hydroxyurea, it is impossible to avoid side effects, such as blackening and atrophy of nails, skin and mucous membrane damage, gastrointestinal discomfort, etc. Shi Shurong/Xie Bielu Director WeChat consultation platform zkxk9999 So, in addition to hydroxyurea, are there other ways to treat thrombocytosis? One is to control the number of platelets. Hydroxyurea is currently one of the first choice drugs at home and abroad, in addition to platelet apheresis, interferon, anagrelide and so on. ☆Platelet apheresis, also known as platelet separation, uses a blood cell separator to separate platelets to achieve the goal of rapidly reducing the number of platelets and improving clinical symptoms. ☆Interferon Interferon is a subcutaneous injection drug. Its therapeutic efficiency is comparable to that of hydroxyurea. It can reduce platelet levels and enhance platelet function. Therefore, it can effectively reduce the incidence of thrombosis and bleeding complications. rate. The dosage is adjusted according to the patient’s tolerance and treatment effect. The application of this drug also requires long-term maintenance treatment. ☆Anagrelide can selectively act on megakaryocytes, tissue megakaryocytes mature and reduce platelets. It has obvious effect on various MPDS with thrombocytosis. The effective rate of treatment of thrombocytosis is also very high, but the cost is also high! Second, the commonly used drugs for antiplatelet aggregation therapy are mainly aspirin. The formation of thrombus is mostly the effect of platelet aggregation. The use of anti-platelet aggregation drugs can help improve the symptoms of the disease. Those with thrombosis can use Gansu or double coumarin anticoagulants. If patients with thrombocythemia have obvious side effects during medication, they can communicate with the attending doctor in time and adopt targeted treatment methods. The treatment method should also be based on the individual’s physical fitness and the development of the disease, the pursuit of stability and effectiveness, rather than rushing for success. For more patient communication help, please pay attention to the WeChat public account [thrombocytosis patients association] xxbzd999

Doctor Shi Shurong: Know the precautions for thrombocytosis, how to reduce the side effects?

Many patients with thrombocythemia are mostly treated with interferon, hydroxyurea, harringtonine and other methods. Although the treatment of thrombocytopenia is effective, the side effects are great and it is easy to repeat after stopping the drug. However, the course of thrombocythemia is relatively slow, so patients need long-term medication. Shi Shurong/Xie Bielu Director WeChat consultation platform zkxk9999 Question: I am a patient with thrombocytosis. Now I am treated with interferon and oral hydroxyurea. The platelets have dropped from 1300 to 560. However, my body reacted very badly after I was given interferon. Mainly dizziness, low-grade fever, fever, leg muscle pain, etc. What should I pay attention to? The doctor recommends: Diagnose essential thrombocytosis, use hydroxyuria, persentine, and interferon for treatment. At present, there are symptoms of dizziness, low fever and other discomforts. In the case of patients with the above, the following points should be noted: 1. Recognize the manifestations of the disease. Primary thrombocytosis is a myeloproliferative disease. Hemorrhagic thrombocytosis caused by the cloning of hematopoietic stem cells. The main clinical symptoms are Fatigue, fatigue, manifested by thrombocytosis, splenomegaly, and bleeding or thrombosis. Routine blood tests often find that the number of platelets is as high as six to seven hundred, or even 1,000 to 3,000. The bone marrow picture is mainly megakaryocytes and platelet hyperplasia. 2. Cognitive treatment methods include platelet apheresis, hydroxyurea and other myelosuppressive drugs, interferon, etc., as well as aspirin, which has anti-platelet aggregation effects. 3. Methods to alleviate side effects Hydroxyurea, interferon and other treatments often require year-round medication, or even lifelong medication. Even so, there is no guarantee that the patient’s condition will not progress to acute leukemia. And it may be accompanied by side effects of varying degrees. The doctors said that for these patients, they can properly cooperate with potentiating and attenuating drugs, which can alleviate side effects, improve their condition, and delay their progression to worse hematological diseases! For more patient communication help, please pay attention to the WeChat public account [thrombocytosis patients association] xxbzd999

Condyloma acuminatum recurred after laser treatment and interferon

   The laser only removes the warts on the surface, not the virus, so it is particularly prone to relapse. However, although interferon has an anti-toxic effect in theory, in fact, interferon cannot directly kill the virus. It only interferes with the growth and reproduction of the virus. It has no specificity to the human papilloma virus that causes condyloma acuminata. Therefore, interferon Treatment cannot control the recurrence of condyloma acuminatum.   If the wart is still recurring after removing the wart with the laser several times, then it should be treated rationally. Change hospitals or doctors as soon as possible and choose other treatment methods to avoid falling into treatment errors. Repeated laser treatment not only accumulates high costs, but may also cause greater local skin damage, causing serious physical and mental harm to patients.   Condyloma acuminatum, as long as the selected treatment method is in line with the purpose of internal and external treatment, it can be cured without recurrence. Because condyloma acuminatum is not a terminal disease, but it cannot be delayed or blindly treated. Secondly, we must adopt a suitable treatment plan, and do not blindly treat it indiscriminately and delay your health.   There are many patients who have undergone multiple relapses after conventional treatment in the clinic, and they have been cured by the Chinese medicine prescription of the National Invention Patent No. 2011101665723, and there is no relapse.  1. According to each person’s condition, a reasonable prescription and targeted treatment will vary from person to person. 2. Chinese medicine is taken internally and externally at the same time. The food is to clear heat and detoxify the whole body, promote blood circulation and remove blood stasis, and improve immunity. The soak is to block the growth environment of genital warts and locally kill the virus. After curing, no scars are left. Contract treatment, no Good full refund.  3. Remote treatment is possible if the condition permits, and treatment can be guided by mailing medicines. However, there is a prerequisite: the patient’s disease cannot be condyloma acuminata in the cavity, such as: the anus, cervix, urethra, oral cavity, etc., the disease in special parts must be treated in the hospital.

Doctor Shi Shurong: When thrombocytosis is diagnosed, what is the bone headache?

In clinical practice, many patients with essential thrombocythemia have their condition discovered by accidental physical examination. At this time, most patients have no obvious symptoms. As everyone knows, if they are not treated in time, as the condition progresses, treatment will become more difficult. Bigger. Shi Shurong/Xie Bielu Director WeChat consultation platform zkxk9999 Patient: The unit physical examination blood routine found that the platelets were as high as 865. I thought it was a mistake. There were still so many rechecks, but I did not have any symptoms. The local hospital’s bone puncture was diagnosed with essential thrombocytosis, and the JAK2 gene was positive. I was hospitalized, but the hydroxyurea intake did not go down much, but it was still around 600. The doctor suggested to take interferon, but I haven’t decided yet. Can this disease be cured? Recently, bone headache, I don’t know if it is caused by this disease! Hematologist: Essential thrombocythemia is a kind of myeloproliferative disease, which is a hematological malignancy. It shows that the platelets continue to rise, but the disease progresses slowly and the course of the disease is long, which can last for more than 10 years or even longer. During treatment, there are two main concerns: 1. Control the number of platelets. Interferon is commonly used and can also be supplemented by other oral chemotherapy drugs. 2. To control the tendency of thrombosis caused by thrombocytosis, it is generally necessary to take aspirin and other anticoagulant and blood stasis drugs for a long time. Suggestions: 1. Check the BCRABL fusion gene. If it is positive, targeted oral drugs such as Gleevec can be used as a treatment option. 2. Add interferon, the general dose is 3 million units, subcutaneously injected once a day, and then gradually reduce the amount of platelets to a long-term maintenance amount. Pay attention to two points when using interferon. Pay attention to adding hepatoprotective drugs at the same time, because this drug hurts the liver; in addition, the first three injections of interferon generally respond with fever and muscle and joint pain. You can add oral medicine in advance to relieve pain. symptom. 3. Bone pain should be related to this disease. Start treatment as soon as possible and don’t delay the condition! All in all, the diagnosis of essential thrombocythemia must be actively treated to control the progress of the disease in time. For patients treated with chemotherapeutic drugs, it can be combined with traditional Chinese medicine for syndrome differentiation, which can effectively reduce the side effects of chemotherapeutics and improve the efficacy. For more patient communication and help, you can follow the WeChat public account [thrombocytosis patient association] xxbzd999

How to treat Xiao Sanyang?

Some fans asked me a question in a private letter. I think it is necessary to do more science. May I ask Dr. Yang, I am a patient with Xiao Sanyang, and my family members have a history of liver cancer. Do I need antiviral treatment? Hepatitis B virus DNA quantification is lower than the lower detection limit. In the case of this patient, he is hepatitis B small Sanyang, and his family has a family history of liver cancer. Then the patient needs to be closely monitored and active antiviral therapy is necessary when necessary. At present, we have two antiviral treatment options, oral nucleotide analogues and intramuscular interferon. Oral drugs can only inhibit the replication of viruses. For patients whose DNA can be measured, oral drugs can inhibit the replication of viruses, thereby blocking the progression of the disease and preventing the occurrence of cirrhosis and liver cancer. This patient has no antiviral treatment, but the test DNA is less than 500, and theoretically no antiviral treatment is needed. Pay attention to regular review. Of course, for such patients, it is recommended to check high-sensitivity DNA, which can detect more than 10 viruses. If the virus can be detected, combined with family history, antiviral therapy should be started before the age of 39. If there is still no virus detected and the surface antigen is less than 1500, consider using interferon to have the opportunity to clear the surface antigen. Interferon has another advantage: it can resist viruses, fibrosis, and tumors. Welcome to follow @liver博士杨明博博士&nbsp., private letter to learn more.

Do antiviral drugs need to be taken for life?

Do antiviral drugs need to be taken for life? Many people are reluctant to take antiviral drugs, and may have the same psychological shadow. Hepatitis B is not cured and needs to be taken for life. Admittedly. Chronic hepatitis B treatment is a long-term process. The antiviral drugs currently on the market include two types of nucleotide analogues and interferon. The former is oral, and the latter is intramuscular. Current nucleoside (acid) analog antiviral drugs mainly inhibit the replication of hepatitis B virus, rather than directly kill the virus. Therefore, patients need to take drugs for a long time to continuously inhibit viral replication, control liver inflammation, maintain stable disease, reduce liver fibrosis, reduce or prevent liver cirrhosis, and even liver cancer, and improve and maintain the patient’s good quality of life. But having said that, long-term treatment is not equivalent to lifelong treatment. For patients with hepatitis B cirrhosis, it is theoretically necessary to take medicine for life. But for some patients with chronic hepatitis, under certain circumstances, there is a chance to cure, and do not need to take medicine for life. For example, after antiviral treatment of some patients, DNA is undetectable, surface antigen is less than 1500, liver function is normal, and there are no contraindications for interferon application. Interferon antiviral treatment may be considered for subsequent use. Welcome to follow @liver博士杨明博博士&nbsp., private letter to learn more.