Purpuric nephritis (HSPN) refers to patients with renal parenchymal involvement in allergic purpura. It is a clinically common secondary glomerular disease that can occur at any age, especially in children. In children with secondary kidney Globular diseases account for the first place (in our department, it accounts for 14.5% of children’s kidney biopsies and 2.94% of adult kidney biopsies), but it is rare in infants and the elderly. The incidence of kidney damage in allergic purpura is quite different, about 20% to 60%, and some can reach more than 90%. Renal involvement mostly occurs within 1 month of the onset of purpura, and most of them occur within 2 months. Within a few months, there were a few cases where hematuria occurred before skin purpura. The occurrence of allergic purpura nephritis is the result of a long-term joint action of various adverse factors. Risk factors include children who often suffer from respiratory infections, bitten by certain insects, especially toxic insects, and their immune system is activated after exposure to allergens. Actively prevent and control all kinds of risk factors for allergic purpura: 1. Develop a reasonable diet, eat less high-calorie, high-fat, high-salt foods, eat more fresh vegetables and fruits. Fasting spicy food and seafood. 2. Quit smoking and limit alcohol 3. Exercise regularly to improve body resistance. 4. Keep warm and prevent colds. 5. Pay attention to rest, avoid mood swings and mental stimulation. Prevent insect bites. 6. Avoid strenuous exercise and appropriate physical activity. 7. Keep warm and prevent colds. 8. Regular urine test, if necessary, check urine microalbumin, 24-hour urine protein quantification, etc. Clinically, allergic purpura can be controlled and cured. In the face of such a severe morbidity situation, it is very important to prevent the disease from getting worse. Prevention needs to be more concerned about health, so as to avoid more comprehensive avoidance of hidden dangers.