There are more and more children with multiple finger (toe) and finger (toe) deformities. Although our operations have achieved satisfactory results for parents every time, we have to see the children who are so young. The heart is still very embarrassed. Whether it is a patient who comes to an outpatient clinic or a patient who is asked online, everyone will ask me the cause of the congenital malformation of the fetus, and I am very puzzled why the pregnancy test does not even show the obvious external deformity of the hand? Some mothers also doubt the necessity of pregnancy tests. 1. The cause of congenital malformation According to the research results, it is found that the cause of fetal malformation may be related to many factors such as genetics, environment, pregnant women’s previous medical history, antibiotics during pregnancy, and chronic diseases of the father. The genetic history of the mother and the chronic history of the father have become risk factors for congenital malformations. Pregnant women’s exposure to toxic substances in the environment (such as pesticides, chemotherapy drugs) are closely related to congenital malformations. Some studies suggest that when a pregnant woman has a previous medical history or has comorbidities such as diabetes and pregnancy-induced hypertension, the internal environment of the pregnant woman is disturbed, so it will adversely affect the normal growth and development of the fetus, and fetal malformations may also occur. The use of tetracycline antibiotics during pregnancy can also affect the fetal bone development. 2. The purpose of pregnancy test? Why can’t the acral deformity be detected during pregnancy? The pregnancy test is to correct certain physical defects of the pregnant woman through inspection. If you find that the pregnant woman has a disease (active tuberculosis, heart disease, diabetes), you must take timely measures. If you cannot continue the pregnancy or the fetus has obvious genetic disease, you can terminate it. Pregnancy. However, even four-dimensional color Doppler ultrasound can not detect all diseases during the obstetric inspection. Abnormal limb (finger and toe) ends are one of them, because the fetus is often in a fist and active state, and sometimes the four-dimensional color ultrasound can not judge the abnormality or loss of the fetus’s fingers, toes or limbs. 3. Pregnancy check is very necessary, because the indication of each check can reflect the health status of the mother and fetus. For example, the examination of urine protein and blood pressure is mainly for the timely detection of pregnancy-induced hypertension syndrome, and the determination of urine glucose is for the detection of glucose metabolism in order to detect diabetes in pregnancy. Weighing is to understand the growth of mother’s weight by checking the weight of each time to indirectly understand the growth and development of the fetus. The measurement of the height of the palace is to calculate the size of the fetus through the data, to detect whether the fetus is stunted, and whether it has become a huge child. The fetal heart rate is measured to determine whether the fetal heartbeat, fetal hypoxia or other abnormal conditions occur. Therefore, for the health of mothers and babies, we must cooperate with the doctor to patiently do every physical examination, do not carelessly. Doctor Yao Jinghui, the Third Affiliated Hospital of Southern Medical University (Guangdong Orthopedics Hospital, Guangdong Orthopedics Research Institute), hopes to help everyone’s health!