Hemophilia is currently not curable. It is a lifelong disease that can only be treated symptomatically, such as blood transfusion or blood transfusion factor. The key is to strengthen care and prevention in daily life to reduce and avoid causing bleeding. There are currently three types of hemophilia, namely hemophilia A, hemophilia B, and hemophilia C. Hemophilia A is due to the lack of blood clotting factor m, while hemophilia B and hemophilia C are lacking. Coagulation factor k and clotting factor knives, these types of hemophilia have certain genetic laws. Both hemophilia A and hemophilia B are sexually recessive. Common is hemophilia A, which is characterized by the onset of males in the family, while females are the carriers of the disease but do not develop the disease. The other two types of hemophilia are both male and female. Home care points Because the disease is a lifelong disease, it is often heavier at onset. Therefore, prevention and care within the family have extraordinary significance for the prognosis of patients and the quality of daily life. 1. Patients and relatives must have a full understanding of the disease, relatives should give patients enough care and love, patients themselves should establish self-confidence, self-reliance, self-improvement of life concepts, self-care, to minimize the incidence of disease and improve Quality of Life. 2. Prevention and care of bleeding (1) “Prevention and care of bleeding”, pay special attention to avoiding trauma, when going to the hospital, explain the condition to the doctor and nurse, and avoid intramuscular injection as much as possible. Do all kinds of safety precautions in the home, try to avoid the use of sharp objects, such as needles, scissors, knives, etc. (2) Normally, when there is no bleeding, proper exercise is beneficial to reduce the recurrence of the disease. However, when there is active bleeding, it is necessary to limit the activity to avoid aggravating the bleeding. (3) When the joint bleeds, you should lie on the bed, fix the limb with splint, put it in a functional position, restrict movement, and apply local cold compress and bandage with elastic bandage. After the joint bleeding stops and the swelling and pain disappear, appropriate joint activities can be performed to prevent deformities and stiffness caused by long-term joint fixation. 3. People who have anemia due to heavy bleeding should strengthen the care of anemia.
. . Some doctors recommend the use of knee pads, but long-term use of such items is not conducive to the operation of the blood. Some patients suffer from severe atrophy of leg muscles due to long-term use of knee pads, so this big method is more beneficial than profit. When there is no bleeding, it is a good choice to take a hot bath, wash with traditional Chinese medicine or apply plasters to “maintain” the diseased joints. If the joint hemorrhage cannot be stopped in time, it will cause more blood accumulation, slow recovery, and greater joint function damage. In the future, this joint will have more chances of bleeding, faster disability, more sins, and more money. Therefore, factors should be added in time for joint bleeding. At that time, a lot of money was spent at once, but recovery is fast, the chance of disability is reduced, and the quality of life is effectively improved. Physical therapy of hemophilic patients is also very important. Be patient and don’t rush for success. Find a doctor who has professional experience in hemophilia. Otherwise, be more conservative and simply don’t do it! Once improper operation results in bleeding, it’s not worth the loss!
1. Hemorrhage of skin and mucous membranes. Because subcutaneous tissue, gums, tongue, oral mucosa and other parts are easy to be injured, it is a site with frequent bleeding. Young children are more common in bleeding/hematoma after forehead collision, but bleeding of skin and mucous membranes is not a characteristic of this disease. 2. Hemorrhage of the joints is a common clinical manifestation of patients with hemophilia. It often occurs after trauma/walking for a long time/exercises and causes synovial bleeding, which is more common in the knee joint, followed by the ankle, hip, elbow, shoulder, and wrist. Joints and other places. Joint hemorrhage can be divided into three stages: A, acute stage: hemorrhage of the tissues in and around the joint cavity, which causes local joint fever, redness, and pain. Following the muscle spasm and limited movement, the joints are mostly in the flexed position. B. Total arthritis: In most cases, due to repeated bleeding, the blood cannot be completely absorbed. The enzymes released by white blood cells and other components in the blood stimulate the joint tissues, forming chronic inflammation and thickening of the synovium. C, late stage: joint fibrosis/joint rigidity, deformity, muscle atrophy, bone destruction, joint contracture leading to loss of function. Repeated bleeding of the knee joint often causes knee flexion, valgus, and fibular subluxation, forming a characteristic hemophilia pace. 3. Muscle bleeding and hematoma often occur in severe hemophilia A, mostly after trauma/muscle activity for a long time, and are more common in hard muscle groups. 4. Hematuria . Patients with severe hemophilia A may have microscopic hematuria or gross hematuria without pain or history of trauma. However, if there is ureteral blood clot formation, there are symptoms of renal colic. 5. Pseudotumor (hemophilic blood cyst) cysts can occur in any part, more common in thighs, pelvis, calves, feet, arms and hands, and sometimes occur To the eye. 6. Hemorrhage after trauma or surgery Various degrees of trauma and minor surgery can cause long-lasting and slow bleeding or bleeding. 7. Bleeding in other parts . Gastrointestinal bleeding can manifest as hematemesis, black stools, bloody stools or Abdominal pain, most patients have primary lesions such as stomach and duodenal ulcers. Hemoptysis is mostly related to primary lesions such as tuberculosis and branch expansion. Nasal epistaxis and sublingual hematoma are usually caused by oral damage in patients with hemophilia A. Tongue Lower hematoma can cause tongue displacement, if hematoma develops to the neck, it often causes breathing difficulties. Intracranial hemorrhage is often the cause of death in patients with hemophilia. 8. Compression symptoms and complications caused by hemorrhage Compression of nerves can cause numbness, loss of sensation, severe pain, muscle atrophy, etc. in the innervated area of the compressed nerve. Bleeding of the tongue, bottom of the mouth, tonsils, posterior throat, anterior neck , It can cause upper airway obstruction, leading to difficulty in breathing, and even suffocation. Local blood vessels are compressed, which can cause tissue necrosis.
Is the disability rate of hemophilia patients high? Can joint disease be recovered surgically? For these two recent patient questions, do the relevant answers below. ——Is the hemophiliac patient’s disability rate high? According to statistics, the disability rate of hemophilia patients in China is very high. Data is available. Coupled with the fact that there are many people with disabilities, the patients spread each other again. This fear of disability spread like a plague. Some parents have spared no effort to overprotect their children as soon as they heard that they will be disabled, or they must take preventive treatment for their children regardless of their financial ability. This can easily lead to too much pressure to reasonably receive targeted preventive treatment, and frequent over-prevention can lead to the occurrence of antibodies. In this regard, it is necessary to properly formulate preventive treatment guidelines, and do not proceed blindly. As long as the protection is done and every bleeding is handled, especially the problem of internal bleeding, you can avoid the occurrence of disability! ——Can joint lesions recover surgically? Many patients with hemophilia have joints that are hard at the early stage of the disease. At this time, apply it to other shapes after it is soft. The principle is very simple. It is estimated that many people can think of it, but it is because Some obstacles, they did not go to implement. The biggest obstacle is estimated to be that forcible joint correction will definitely cause bleeding, especially some doctors, some of them even dare not give intravenous injections to hemophilia patients, and some see hemophilia patients step back three steps, fearing to touch Broken, let alone correct the joints. Sometimes knowledge is right, but it is wrong to use it. Hemophiliacs do bleed easily, but it only takes a little longer to clot. Hemophiliacs are indeed afraid of bumps, but bumps do not necessarily bleed. Compression and correction of joints are not easy to bleed. The most terrible thing is actually “spontaneous bleeding” of joints. -Patients with hemophilia should not easily choose surgery. Even patients with stiff joints, it is better to avoid surgery or try not to do it. Conservative treatment is the first consideration. To do so, first choose the operation with low risk. As for joint replacement surgery, it should be considered last when it is absolutely necessary. Joint replacement, first of all, is the high cost, then the problem of the service life of the artificial joint, the problem of the artificial joint being scrapped in advance, and the problem of postoperative recovery. Finally, it is still artificial, and it is definitely not easy to use. If you have any questions about this article or the disease, please feel free to follow us on WeChat and find out more: xueyb120
Esperoct (turoctocogalfapegol/N8-GP) long-acting new drug for hemophilia. It is currently on sale in the United States for adults and children with hemophilia A. There are three points about the indications for treatment: (1) conventional preventive treatment; (2) on-demand treatment and control of bleeding episodes; (3) perioperative bleeding management; Esperoct is a prolonged half-life coagulation factor VIII product, and the standard half-life Compared with factor VIII products, the half-life of Esperoct is 1.6 times longer in adult/adolescent patients and 1.9 times longer in children. This will help reduce the bleeding frequency of the disease and the number of administrations. If you have any questions about this article or the disease, please feel free to follow us on WeChat and find out more: xueyb120
For ordinary people, dental bleeding is a common phenomenon when brushing their teeth, but it may not be a small matter for patients with hemophilia, because the patient lacks coagulation factors, the blood coagulation function is too poor, and the blood flow may not stop, and a lot of bleeding. The child is the heart of the parents. When the child is sick, the parents are very anxious. Can children brush their teeth for hemophilia? A considerable number of parents of children with blood diseases believe that brushing their teeth will increase the bleeding in the mouth of the child. Probability, some parents think that gargle can replace tooth brushing. In fact, gargle is just the first step of oral cleaning, and the food residues left in the mouth cannot be completely removed only by gargle. Brushing your teeth is an important way to maintain oral hygiene and massage the gums. But this does not mean that children with blood diseases must brush their teeth. Whether they can brush their teeth depends on the specific situation of the child. It cannot be generalized. Generally, it is considered that children can brush their teeth when the following conditions are met. The first point is that the child’s platelet count is above 50×109/L and the white blood cell count is above 1.0×109/L. You should not brush your teeth within this range. The second point, parents need to pay attention to the child’s oral cavity without bleeding, ulcers, and no abnormal blood clotting, if this is not the case, it is not suitable for brushing teeth. Third, observe the children, or go to the dentist to check for periodontal diseases such as gingival hyperplasia, and those with periodontal diseases are also inappropriate. Fourth, this period of time is acceptable after the deciduous teeth of the child have been shed for more than 24 hours and the cavity has been repaired for 48 hours. For patients with hemophilia, hemostasis should be always available at home. When the teeth are bleeding, stop bleeding in time to avoid massive bleeding. If the bleeding is not effectively controlled, it is recommended to go to the hospital for treatment immediately. Patients with hemophilia should also pay attention to protect themselves when brushing their teeth daily, and the intensity must be light, not to damage the gums, to avoid bleeding. People with hemophilia are more vulnerable, it may be caused by a small wound
If a pregnant couple wants to know if their child has the genes that cause hemophilia, the baby can be tested while the fetus is still in the womb. This is called prenatal testing. The laboratory test for fetal cells is exactly the same as the DNA test for determining whether a woman is a carrier, that is, DNA polymorphism test or direct mutation test (see the above “What is carrier test?”) if You are a hemophilia patient who is planning to raise a child. The hemophilia comprehensive care team can provide you with detailed information about various existing tests. Genetic counselors can also help you choose and decide how to proceed. Each couple’s situation is different, and they have the right to decide whether prenatal testing is the best option for them. Many doctors advise women to test before pregnancy to see if they are carriers. This allows you to make better judgments, because if the test results prove that the mother is not a carrier, there is no need for prenatal testing. The following two prenatal tests can determine whether a fetus carries a hemophilia gene: Villous biopsy (CVS): This is a genetic test that can be performed sooner than amniocentesis after pregnancy. Villous biopsy can be performed 9 to 10 weeks after conception. The method is to take a very small sample of chorionic villi (part of the placenta) from the inside of the uterus for laboratory testing. The risk of miscarriage caused by villi biopsy is very low. Amniocentesis: This test has been used for many years. Usually about 16 weeks of pregnancy. The method is to take a small amount of amniotic fluid from the amniotic sac in the uterus as a sample for testing. Amniotic fluid contains cells from the fetus (the fetus is in the womb). The rate of miscarriage caused by amniocentesis is also very low, only about 0.5%. Test the DNA of fetal cells to determine if it has a mutation that causes hemophilia. Under any circumstances, a female carrier should conduct a prenatal test to determine her factor Ⅷ or Ⅸ level in the laboratory. This is especially important for carriers who have increased bleeding.
Hemophilia patients often have low education and low income, but medical expenses are very expensive, and many people often cannot receive the most basic treatment, which makes their living conditions worse. People with mild hemophilia are relatively less affected, and some people can live a better life. In recent years, relevant people have called on the government to eliminate various unfavorable policies for hemophilia patients, strengthen the attention to hemophilia patients, and enable hemophilia patients to live a normal life. 1. Carry out the propaganda of hemophilia knowledge in the whole province, let the society have a correct understanding of hemophilia, avoid and reduce the discrimination of hemophilia. 2. Facilitate the investigation of AIDS and hepatitis C infection in patients who have previously used whole blood and cryoprecipitate hemophilia in the province. 3. To train medical staff in counties and cities to hemophilia medical knowledge training to improve the medical environment of hemophilia patients. 4. Appeal to all sectors of the community to provide loving care to solve or partially solve the medical expenses of patients and provide life assistance. We hope to live a normal life under the care of all walks of life and make due contributions to the country and society!
——Can bone marrow transplantation cure hemophilia? Question: Hello, hemophilia A has been diagnosed for many years and has a family genetic history. Because the joint cavity bleeds repeatedly to cause the current slight deformation, the factor content belongs to severe hemophilia. Bleeding is relatively frequent. Our doctors said that if the momentum of this development is followed, it may be that I will spend the next half of my life in a wheelchair, which is really very helpless. I recently heard that a hospital can cure hemophilia with transplantation. Is this true or false? Can hemophilia be cured by bone marrow transplantation? Medical Answer: Deceptive. Bone marrow transplantation cannot cure hemophilia, nor can it be used to treat hemophilia. It can be funny to say that medical science has not yet figured out which organ of the human body made the eight factor (the data is said to be synthesized by the liver). It was originally thought that it was made by the spleen, so it was done as a spleen transplant, but the result was not. The result is in the liver context chapter, but still no result. The current treatment for hemophilia is to actively deal with every bleeding. If there is no way to control spontaneous bleeding, it is recommended to take preventive treatment measures, try to avoid and reduce the number of bleeding, mainly to reduce the rate of teratogenic disability. Every patient and family member of the child has to master the judgment and treatment of bleeding (the popular science articles have been popularized one by one). It is a pity to tell the hemophilia that hemophilia is currently not cured, gene therapy is still being explored, and it has not yet been applied to domestic clinical practice. But the experiment is in full swing, and I believe that in the near future, hemophilia will be completely overcome! If you have any questions about this article or the disease, please feel free to follow us on WeChat and find out more: xueyb120
Hemophilia is currently not curable. It is a lifelong disease that can only be treated symptomatically, such as blood transfusion or blood coagulation factor transfusion. The key lies in strengthening care and prevention in daily life to reduce and avoid bleeding. There are currently three types of hemophilia, namely hemophilia A, hemophilia B, and hemophilia C. Hemophilia A is due to the lack of blood clotting factor m, while hemophilia B and hemophilia C are lacking. Coagulation factor k and clotting factor knives, these types of hemophilia have certain genetic laws. Both hemophilia A and hemophilia B are sexually recessive. The most common is hemophilia A, which is characterized by the onset of males in the family, while females are the carriers of the disease but do not develop the disease. The other two types of hemophilia are both male and female. The main point of home care is that the disease is a lifelong disease, and it is often heavier at onset. Therefore, prevention and care in the home have extraordinary significance for the prognosis of patients and the quality of daily life. 1. Patients and relatives must have a full understanding of the disease, relatives should give patients enough care and love, patients themselves should establish self-confidence, self-reliance, self-improvement of life concept, do self-care, minimize the incidence of disease and improve Quality of Life. 2. Prevention and Nursing of Bleeding (1) “Prevention and Nursing of Bleeding”, pay special attention to avoiding trauma, when going to the hospital, explain the condition to the doctor and nurse, and avoid intramuscular injection as much as possible. Do all kinds of safety precautions in the home, try to avoid the use of sharp objects, such as needles, scissors, knives, etc. (2) In the absence of bleeding, proper exercise is beneficial to reduce the recurrence of the disease. However, when there is active bleeding, it is necessary to limit the activity to avoid aggravating the bleeding. (3) When the joint bleeds, you should stay in bed, fix the limbs with splints, put them in a functional position, restrict movement, and apply local cold compress and bandage with elastic bandage. After the joint bleeding stops and the swelling and pain disappear, appropriate joint activities can be performed to prevent deformities and stiffness caused by long-term joint fixation. 3. People who have anemia due to heavy bleeding need to strengthen anemia care
Sleeve-sized implants enable guinea pigs and monkeys to produce a protein that treats hemophilia. Animals do not suffer from bleeding disorders, so the study did not directly test whether the implant can reverse hemophilia. But blood sample analysis showed that the implant turned a natural protein in an animal into a certain number of useful active forms, called FactorVIIa, which is currently used in the treatment of hemophilia. The researchers are Dr. Harvey Pollard of Uniformed Services University School of Medicine in Maryland and his colleagues. Hemophilia is caused by the lack of a procoagulant protein (FactorVIII). Doctors can import this protein to patients for treatment. But 15% of patients produce antibodies that prevent the activity of proteins imported into the body. These patients can be imported into FactorVIIa, but the drug is expensive and the protein will break down quickly. Implants can avoid the above two situations, and will not make the body produce antibodies. The implant is a porous chamber containing substances that can transform FactorVII into FactorVII. The researchers placed three implants in the abdomen of the monkey. As a result, FactorVIIa was produced in the monkey one month before the implant was taken out for observation. Scientists hope to conduct human trials in one to two years.
The path of growth of children with hemophilia|Parents need to recognize these misunderstandings! There is nothing wrong with exercising caution for hemophiliacs, especially in life. But many things can’t be careful. Patients still have to exercise when they should exercise, and still exercise when they should exercise. The doctor pointed out that strong muscles are a prerequisite for reducing bleeding or even not bleeding! This is very important! Many cases are bedridden from an early age, leading to hemophilia patients from childhood, growing muscle atrophy and obesity. This will further promote foot weakness or increase foot burden! Unnecessary daily life Be careful not to go too far to avoid taboos, such as exercise. And like some ascents, careful crossing the road and not fighting, etc., this is necessary. Regarding food supplements, don’t overdo it for patients with hemophilia. Patients with hemophilia are the same as other normal children except that their own blood coagulation factor content is lower than normal! As long as the nutrition is normal. Don’t over-purchase all kinds of health products and nutritional products for children This will excessively increase the excess fat and cause weight gain! The diet should be carried out to a certain degree, with reasonable combination of meat and vegetables. Regarding pain, many hemophiliacs suffer because the family’s economy does not allow it. In fact, this is wrong. When bleeding, the factor should be infused at the first time (most of the pain is internal bleeding). Don’t be afraid of losing the risk of infection. In addition, the medical insurance policies around the country have also added the reimbursement process for blood product transfusions, which can further reduce the financial burden of hemophiliacs. All in all, bleeding is the only way to stop bleeding as soon as possible. In the long run, patients with hemophilia should still actively treat every bleeding and prevent it to stabilize the factor content. There are also many naughty children who are educated about hemophilia. Some parents scolded their children when they fell naughtily. In fact, this is wrong. This will increase the chances of the child’s luck. The child will not dare to say that he has fallen because of fear of being scolded. The hematoma is too large to be treated. At this time, the best treatment time has been missed and the child’s body parts will be damaged. After blood accumulation, it swells to deform the joints, and the disability rate increases! Suggest that this situation can be verbal warning, family members of the children pay attention to words, do not be too extreme. When a person is injured, his heart is very fragile, which will make him think that you do not love him. If he is psychologically beaten, punched and kicked, it may make his mental health worse. Regarding the education path of children with hemophilia, every parent should recognize the misunderstanding and avoid touching! If you have any questions about this article or the disease, please feel free to follow us on WeChat and find out more: xueyb120
——Hemophilia bleeding medication, what is the standard for hemostasis? Children with hemophilia can easily judge when they speak, let alone adults, and can feel timely feedback about their feelings. What is the blood standard? That is, the pain is reduced, or the pain is gone. Especially the bleeding of the joint is very painful in itself, and the feeling of this pain relief after the hemostasis is obvious. As for muscle bleeding, as long as the bleeding does not continue to swell, the pain does not increase or even alleviate for a period of time, basically you can directly judge the hemostasis! Feelings of self-judgment are very important in this regard, you can directly ask the person with hemophilia. If the child is still unable to speak, parents need to observe more. Focus on key points-Reasonably handle every bleeding situation, including hemostatic treatment, analgesic, anti-inflammatory, anti-tumor, nursing and other measures, which can greatly reduce the teratogenic disability rate of patients. If you have any questions about this article or the disease, please feel free to follow us on WeChat and find out more: xueyb120
Some women who have been suffering from multiple menstrual problems for a long time may have hemophilia, but many women do not know anything about it. In an interview with Lianhe Zaobao, senior consultant doctor Chen Xinlong, director of the Hemophilia Medical Center of the Central Hospital, said that foreign research data estimated that about 10% of women who face menstrual problems actually suffer from a lesser known blood The type of friend disease is called “Willebrand’s disease”. He said that there are more than 50 local patients with Willebrand disease registered with the hemophilia registry, and men and women account for half. However, if we estimate based on 10% of foreign countries, we believe that there are still many female hemophiliacs who have faced menstrual problems and have not come to the clinic or are misdiagnosed. Dr. Chen said: “Especially young women, if faced with menstrual problems for a long time, but after gynecological and obstetrician examination can not find any cause, there is no pathogenic factors such as fibroids, polyps, endometriosis, The patient should consider receiving a detailed blood test to see if he has Willebrand’s disease. This can also avoid unnecessary hysterectomy.” Like other types of hemophilia, Willebrand’s Other symptoms of the disease include easy bruising or swollen joints, blood flow after surgery (even simple tooth extraction procedures), abnormal nosebleeds or bleeding gums, etc. Dr. Chen said that hemophilia is caused by the inheritance of sex chromosome genes. It is a genetic disease in which blood coagulation is particularly slow due to the lack of blood coagulation factors. If there is a lack of a coagulation factor, the bleeding time may be prolonged. The human body relies on the coagulation of blood to stop bleeding after injury and help recovery. Normal blood clotting can prevent blood stasis after trauma, and can prevent bleeding caused by minor injuries in daily life from reaching muscles and joints. Normal blood clotting is the result of many substances in the blood working together, some of which are called coagulation factors. Hemophilia is divided into several types, Willebrand’s disease is one of them. In addition, hemophilia A is the most common of all types, and it is caused by the lack of a clotting factor called factor VIII. Hemophilia B is a lack of factor IX. Dr. Chen said that in fact, the two types of patients with hemophilia A and B are usually male, and females are only genetic. The Villebrand disease, which is also very common locally, is common to both male and female patients. Although most people have only heard of the two types of hemophilia A and B, the number of patients with Willebrand’s disease is actually much higher than that of patients with hemophilia B. Hemophilia patients are generally not serious, and only a few will be cured because of cerebral hemorrhage or massive stomach bleeding. In general, the more severe the patient’s condition, the earlier the blood stasis and bleeding will appear. As for children with hemophilia, it is usually when they are eight or nine months old, because of crawling and easy to fall, many long-lasting bruises appear on their bodies before they are noticed. Parents should bring their children to the doctor as soon as possible to avoid serious accidents. Dr. Chen said that so far, hemophilia cannot be cured, it will be accompanied by a lifetime. However, by strengthening comprehensive care and preparing supplements that contain the lack of blood coagulation factors, even severe bleeding conditions can be controlled and lead to a normal life. When bleeding in joints and muscles and various forms of surgery, including foreskin cutting and tooth extraction, patients need treatment. Hemorrhage in other tissues or injuries after an accident may also require treatment. Since the establishment of the National Hemophilia Registry in 1995, nearly 400 patients have been registered so far, nearly half of the patients with hemophilia A. From the perspective of genetic theory, encouraging patients with hemophilia or those with genes to undergo testing and counseling before family planning can help reduce new cases of hemophilia. Central Hospital was recently the only local hospital authorized to provide international hemophilia medical training services. This honor was awarded by the International Hemophilia Medical Federation, which affirmed the perfect medical equipment and service quality of the Hemophilia Medical Center of the Central Hospital. There are 30 centers worldwide recognized by the international organization that can provide medical training services on hemophilia. Early detection to prevent accidents Aisha (50s) has been suffering from many menstrual problems for many years. It was not until 7 years ago that she consulted with Dr. Chen Xinlong that she discovered that it was Weilerbrand’s disease that caused menstruation. She said that from the year
If you want to reduce the bleeding pain of hemophilia, you can try this method-ice compress! Nursing measures for hemophilia patients after bleeding can be applied with ice to promote vasoconstriction, reduce local metabolism, reduce the release of inflammatory factors, slow down nerve conduction velocity, achieve the purpose of stopping bleeding and reducing swelling, and reducing pain, which is conducive to damage to the bleeding site Early repair of the organization. Adaptation of ice compress-patients with hemophilia can apply ice compress if they have acute sprain, inflammation, swelling and other problems. How to apply ice-first put small ice cubes or ice-water mixture in a plastic bag and wrap it with a dry towel. Secondly, apply ice to the swollen and painful area, and can not be placed directly on the wound. Finally, it is necessary to pay attention to the ice compress every 20-30 minutes, intermittent 2 hours, within 2 days after injury or surgery. Remarks should be noted that-if hemophilia patients appear blue and black on the surface of the skin after ice application, they should stop immediately. Ice application is not suitable for those with skin rupture or rash. In addition, cold and hot can be used according to the situation. . If you have any questions about this article or the disease, please feel free to follow us on WeChat and find out more: xueyb120
[Calcium supplementation]-Every issue that hemophilia patients need to pay attention to Calcium supplementation is very important for hemophiliacs. Most patients have less exercise and lower bone density, which will further lead to insufficient calcium in the bones, and the older they are, the more problem calcium supplementation becomes. In addition, it is also a good habit for patients to do medical examinations! Relevant analysis is made below. Calcium deficiency can cause a variety of problems, such as cramps, soft legs and legs, poor sleep, irritability, joint pain, and mental distress. In severe cases, because the bones are too brittle, some orthopedic surgery can not be done, and it can also be A light fall can cause a fracture. It is important to know that a fracture is equivalent to a major operation for a patient with hemophilia. Therefore, patients with hemophilia must actively supplement calcium. There are many methods, such as: strengthening exercise, sunbathing, kidney supplementing, foot bathing before bed, and eating calcium-containing foods (milk, beans, and diet preferably have beans every day) , Calcium supplements, etc. Ps: Note that smoking and drinking, as well as drinking carbonated drinks, strong tea, coffee, these will cause calcium loss. Physical examination is also a very important basic habit for patients with hemophilia. This needs to be done from small to most, and requires one or two comprehensive physical examinations every year. There are many physical examination items. The most important thing is blood routine (excluding some infectious diseases, such as hepatitis A, hepatitis C, AIDS, etc.), blood lipid three items, liver Function, renal function, urine routine, electrocardiogram, blood pressure, blood sugar, B-ultrasound, chest X-ray, male and female specialty, internal medicine, surgery, etc. The more important ones are general examination, facial features and so on. If you are unclear about the medical check-up items, you can consult a doctor. Generally, doctors who understand the comprehensive medical check-up items know it, or you can go directly to the medical check-up center if possible. It is convenient and professional. The purpose of this is to find the problem as soon as possible and solve it as soon as possible. It is also to deal with physical problems. Of course, the sooner the problem is solved, the better, and the more money is saved. Regular medical examination is also an opportunity to remind yourself to find problems in time and prevent them in time, so you can spend less money on unnecessary medical treatment. If you have any questions about this article or the disease, please feel free to follow us on WeChat and find out more: xueyb120
Return to normal life! Standard treatment is expected to make patients with hemophilia [away from disability] clinical standard treatment for hemophilia is prophylactic factor replacement therapy since childhood, that is, regular infusion of coagulation factors to keep patients’ plasma coagulation factor levels above 1% To prevent spontaneous bleeding. A typical example of hemophilia is that Alex Dorset, a British patient with hemophilia A, began regular infusions of FVIII from an early age and later became a professional cyclist, winning several European and world championships. The treatment of complications and comorbidities in patients with hemophilia is very different from that in general patients. Since the end of the 1990s, the country has started a multidisciplinary cooperation model for diagnosis and treatment of hemophilia. It has formed a team (MDT) of multidisciplinary experts including hematology, pediatrics, orthopedics, physical rehabilitation, and stomatology. In more than 20 trials, more than 400 cases of orthopedics and stomatology were successfully performed on patients with hemophilia. Thousands of patients with hemophilia received physical therapy and rehabilitation. The comprehensive treatment of hemophilia patients is in a leading position in the country. In addition, in addition to plasma and recombinant coagulation factors, the introduction of improved, extended half-life FVIII (about 1.5 times longer) and FIX (about 3 times longer) and the combination of treatments to improve the activity of coagulation factors also help to better treat blood Friends. Amystuzumab, which was launched some time ago, is an activated FVIII mimic and has a half-life of about 4 weeks. It has good effects on hemophilia A patients with or without inhibitors! Gene therapy for hemophilia has made significant progress, and it is expected to cure some patients with hemophilia. But the new therapies are expensive and difficult to popularize in the short term. If you have any questions about this article or the disease, please feel free to follow us on WeChat and find out more: xueyb120
Accidental injuries in life | How should hemophiliacs deal with wound bleeding? Because wounds in hemophilia patients will always bleed after injury, it will lead to slower healing, and long-term exposure of unhealed wounds to the air will easily breed bacteria, which will further cause inflammation, which makes it more difficult for inflammatory wounds Healing. Therefore, it is recommended that when hemophilia patients suffer from trauma bleeding, the first step to increase the factor content is the first, so that they have the ability to promote hemostasis, and then do the wound treatment. Hemostasis is as important as wound inflammation-some patients with hemophilia are repeatedly wounded due to inflammation of the wound, and later the wound becomes larger and larger. Do not wait until the inflammation is disinfected. It is important to prevent it from being recommended. Iodophor, alcohol, hydrogen peroxide, etc., these are very common disinfecting drugs. In addition, the location of the “love” bleeding involved in hemophilia should also be frequently discussed. Especially the knee, ankle and elbow joints. Repeated bleeding without timely treatment will damage the cartilage and bones of the joint site, leading to chronic arthritis and disability. The most severe muscle bleeding occurs in the iliopsoas muscle (in front of the groin area), forearm, and lower leg. Partial bleeding related to hemophilia is life-threatening and requires immediate treatment, including bleeding in the head, throat, and iliopsoas muscle. In order to reduce the probability of this risk. In summary, it is recommended that regardless of the age of hemophilia, it is necessary to pay attention to daily protective measures and preventive treatment programs for those with frequent bleeding. WeChat search Yisuo will pay attention to the patient will know more: xueyb120
The principle of hemophilia treatment is mainly preventive treatment, and patients and their families need to understand the nature of the disease, knowledge of prevention and treatment, and precautions. Everyone pays more attention to the popularization of therapeutic drugs. Among them, doubts about female contraceptives are indeed used clinically in the treatment of hemophilia. What are the few commonly used treatments for hemophilia? 1. Drugs that inhibit fibrinolysis. Commonly used drugs include 6-aminocaproic acid and hemostatic acid. 2. Danazol is a synthetic androgen, 400 ～ 600mg per day can increase the level of factor Ⅷ activity. 3. The female contraceptive pill, norethisterone, 1 mg per day, used continuously for 1 to 2 months, can increase the concentration of factor Ⅷ, and has a certain effect on hematuria and deep tissue hematoma. 4. Adrenal cortex hormones have a certain effect on reducing bleeding, promoting acute hematopoietic absorption, and reducing local inflammation. Remarks: Notes on daily life of patients with hemophilia? For patients with hemophilia, surgery should be avoided as much as possible. If surgery must be performed, adequate preparation should be made before surgery, and medical treatment should be sought in time for bleeding. For patients with hemophilia, intramuscular or subcutaneous injections should be prohibited. Compress for at least 5 minutes after venipuncture to prevent bleeding. Do not take aspirin, indomethacin, pansentine and other drugs that inhibit platelet function and drugs that dilate blood vessels. In case of minor injury, hemostatic can be locally compressed with gelatin sponge, fibrin foam, thrombin, epinephrine, etc. The hemostatic agent formulated abroad contains cryoprecipitate, thrombin, and aminocaproic acid for local treatment of hemophilia patients. The effect is better. Alternative treatment is the main treatment method for bleeding in this disease. The available preparations are fresh plasma and fresh frozen plasma, cryoprecipitate preparation, prothrombin complex concentrate (PCC), Fvm concentrate and recombinant FⅧ and FIXⅨ (rFⅧ and FIX). Targeted hemophilia is discovered early, diagnosed early, treated early, and takes preventive measures. More and more patients have obtained a good quality of life! WeChat search Yisuo will pay attention to the patient will know more: xueyb120
The types of hemophilia include hemophilia A, hemophilia B, and hemophilia C. The ratio of the prevalence of hemophilia A to the prevalence of hemophilia B is 5: 1. Basic knowledge about the disease: Hemophilia A is also called factor Ⅷ deficiency or anti-hemophilia factor A deficiency. True hemophilia and anti-hemophilia globulin deficiency is a traditional hemophilia; hemophilia B is also called factor Ⅸ deficiency or plasma thromboplastin (PIC) deficiency; hemophilia C is also called blood clotting Factor Ⅺ deficiency, plasma thromboplastin (PTA) deficiency. Among the congenital hemorrhagic diseases, hemophilia is the most common, especially hemophilia A, accounting for about 85%, followed by hemophilia B, and the least common is hemophilia C. Inexplicably sick? Understand the inheritance of hemophilia “A, B, C”. Hemophilia A and hemophilia B are inherited in the same way, both are recessive inheritance of sex chromosomes, male onset, female transmission, there are three cases of heredity. ① Male patients are married to normal women, the boys are normal, and the girls are passers. ② The marriage between the female transmitter and the normal male, the boy can be a hemophilia patient, or it can be normal, and half of the girl is the transmitter, and half is normal; The probability is 50%, which means that about 1/2 of the boys born are normal. Among the girls born, there may be hemophilia or transmitter. The inheritance of hemophilia C is autosomal incomplete recessive inheritance. Both men and women can get sick. Hemophilia A can be caused by genetic mutations in addition to hereditary methods. It may also be secondary to liver diseases such as cirrhosis and hepatitis, liver cancer metastasis, extrahepatic cancer metastasis, certain blood diseases, such as acute and chronic leukemia, lymphoma, etc. as well as systemic lupus erythematosus, rheumatoid arthritis, uremia These secondary hemophilia are called acquired hemophilia. Although this disease is a rare disease around us, hemophiliacs are found all over the world. Once found, it is necessary to actively take preventive or supportive maintenance treatment according to the actual situation. Strive for a normal quality of life and integrate into a healthy and normal life. WeChat search Yisuo will pay attention to the patient will know more: xueyb120