After many people have kidney disease, they become uremia indistinctly. It is even unclear when the kidney started to be “injured”. Uremia is not a single-onset disease, it is the end stage of the development of chronic kidney disease, that is, the state of kidney failure. So where does chronic kidney disease come from? Chronic kidney disease is mainly divided into two categories, one is primary kidney disease, and the other is secondary kidney disease. 1. Primary nephropathy Primary nephropathy refers to a disease that originates inside the kidney, such as glomerulitis, pyelonephritis, occult nephritis, and kidney stones. If it does not recover after more than 3 months, and the relevant examination indicators are always abnormal, or the effective glomerular filtration rate is less than 60%, it can be regarded as “chronic kidney disease”. 2. Secondary kidney disease is caused by other diseases. The secondary kidney disease, such as high blood pressure, is like pressing a mountain on the kidney. It is likely to cause excessive blood vessel pressure, protein leakage, and structural effects on the filter. The destruction eventually leads to hardening of the kidneys. Another example is diabetic nephropathy, which has become the second leading cause of uremia. Excess blood sugar will produce a large amount of glycosylation end products, which are deposited in the kidneys, block the renal tubules and blood vessels, cause various inflammatory reactions or microvascular lesions, and eventually “stretch” the glomeruli. In addition, gout, lupus erythematosus, and hyperlipidemia are all high-risk factors. If it cannot be cured or contained effectively, it can easily develop into uremia.